| 中文关键词: MACC1 HGF/c-Met 宫颈癌 卵巢癌 子宫内膜癌 |
| 英文关键词:MACC1 HGF/c-Met cervical cancer ovarian cancer endometrial cancer |
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| 摘要点击次数: 2006 |
| 全文下载次数: 909 |
| 中文摘要: |
| 摘 要：MACC1是新近发现的与结肠癌的发生和转移密切相关的基因。体外研究发现MACC1能够诱导肿瘤细胞的增生、增殖及迁移，是HGF/c-Met信号通路中Mrt基因的关键调节因子，在妇科肿瘤的发生及发展中也起主要的作用。近年发现MACC1异常表达与宫颈癌、卵巢癌和子宫内膜癌的转移和预后密切相关，可作为判断这些恶性肿瘤转移和预后的肿瘤标志物。全文就MACC1与妇科恶性肿瘤的关系作一阐述。 |
| 英文摘要: |
| Abstract：MACC1 was recently identified a key gene controlling tumor growth and metastasis. The study found that MACC1 was able to induce cell proliferation，migration，and apoptosis. MACC1 was an important regulatory factor of the HGF/c-Met signaling pathway；it also played a key role in gynecological cancer. In recent years，scientists have found that the abnormal expression of MACC1 closely associated with metastasis and prognosis of cervical cancer，ovarian cancer and endometrial cancer. The relationship between MACC1 and gynecological cancer is analyzed in this paper. |
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