| 周莉莉,唐咸艳,李志革.BRCA-1与IGF-1R在CerbB-2高表达乳腺癌组织中的表达及意义[J].中国肿瘤,2015,24(11):961-965. |
| BRCA-1与IGF-1R在CerbB-2高表达乳腺癌组织中的表达及意义 |
| Expression of BRCA-1 and IGF-1R in Breast Cancer with High CerbB-2 Expression and Its Clinical Significance |
| 投稿时间：2015-08-11 |
| DOI：10.11735/j.issn.1004-0242.2015.11.A015 |
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| 中文关键词: 乳腺癌 BRCA-1 IGF-1R 免疫组织化学 预后 |
| 英文关键词:breast cancer BRCAL-1 IGF-1R immunohistochemistry prognosis |
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| 中文摘要: |
| 摘 要：［目的］ 探讨BRCA-1和IGF-1R在CerbB-2高表达乳腺癌组织中的表达及临床意义。［方法］ 应用免疫组织化学SP法检测BRCA-1和IGF-1R在29例CerbB-2高表达的乳腺癌组织、20例CerbB-2低表达的乳腺癌组织和10例乳腺增生症组织中的表达情况。［结果］在CerbB-2高表达的乳腺癌中，BRCA-1表达与组织学分级、腋窝淋巴结转移、术后复发转移密切相关（P＜0.05），与患者年龄、肿瘤大小、雌激素及孕激素受体状况无关（P＞0.05）；IGF-1R表达与患者年龄、肿瘤大小、组织学分级、腋窝淋巴结转移、术后复发及雌激素与孕激素受体状况无关（P＞0.05）。Kaplan-Meier生存分析结果表明BRCA-1和IGF-1R的表达与总生存期均无明显相关（P＞0.05）。［结论］ 乳腺上皮中BRCA-1蛋白的表达减少与缺失和IGF-1R的表达增加与CerbB-2高表达的乳腺癌的发生和发展密切关系，两者有望成为代替或协助CerbB-2判断乳腺癌恶性程度、预后及指导治疗的生物学新指标。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the expression of BRCA-1 and IGF-1R in breast cancer with high CerbB-2 expression and its clinical significance.［Methods］ The expression of BRCA-1 and IGF-1R in 29 breast cancer tissue with high expression CerbB-2，20 breast cancer tissue with lower CerbB-2 expression and 10 cases with hyperplasia of mammary gland was detected by immunohistochemistry SP method. ［Results］ In 29 cases of CerbB-2 high expression in breast cancer tissue，the cases of lower expression and missing of BRCA-1 was increased significantly(P>0.05)；The positive expression rate of IGF-1R in breast cancer of CerbB-2 high expression was significantly higher than that in breast cancer of cerbB-2 lower expression and hyperplasia of mammary gland tissue. In breast cancer tissue of CerbB-2 high expression，the expression of BRCA-1was significantly related to the histological grade，axillary lymph node metastasis and the postoperative recurrence metastasis(P<0.05)，but not related to age of patients，size of tumor，ER or PR(P>0.05). The expression of IGF-1R was not correlated with age of patients，size of tumor，histological grade，axillary lymph node metastasis，recurrence of tumor，ER or PR(P>0.05). Kaplan-Meier survival analysis result showed that the expression of BRCA-1 and IGF-1R was not associated with overall survival(P>0.05).［Conclusion］ The lower expression or absent of BRCA-1 and overexpression of IGF-1R in mammary gland epithelial were significantly related to the generation and development of the breast cancer of CerbB-2 high expression. They could become new biological parameters which can replace or assist CerbB-2 judging the malignant extent，prognosis of breast cancer and guiding the treatment. |
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