胡思思,凌志强,葛明华.miR-130在恶性肿瘤中作用研究进展[J].中国肿瘤,2014,23(2):136-140. |
miR-130在恶性肿瘤中作用研究进展 |
Research Progress in the Effect of microRNA-130 on Carcinoma |
投稿时间:2013-05-13 |
DOI:10.11735/j.issn.1004-0242.2014.02.A012 |
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中文关键词: microRNA-130 肿瘤 化疗耐药性 |
英文关键词:microRNA-130 neoplasms chemoresistance |
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中文摘要: |
摘 要:微小RNA(miRNAs)是一组在转录后水平上调节基因表达的非编码RNA分子,通常结合到mRNA分子上导致靶mRNA降解或翻译抑制。microRNA-130(miR-130)包括miR-130a和miR-130b。研究发现,miR-130在多种机制调控下,在一些肿瘤中发挥癌基因作用,而在另一些肿瘤中发挥抑癌作用,并且与多种肿瘤化疗耐药性有关。本文就miR-130在肿瘤中的作用做一综述。 |
英文摘要: |
Abstract:MicroRNAs(miRNAs) are short non-coding RNA molecules those regulate post-transcriptional gene expression. MiRNA will bind to mRNA resulting in target mRNA degradation or translational repression. Researches confirm that the microRNA-130(miR-130) family,which consists of miR-130a and miR-130b,correlates with tumor genesis,metastasis and multiple drug resistance,and is regulated by various mechanisms. We review the relationship between miR-130 and neoplasms. |
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