| 汪令伟,汪 程,王 林.肿瘤标志物GW112在胃癌及结直肠癌等消化道肿瘤中的研究进展[J].中国肿瘤,2013,22(11):905-908. |
| 肿瘤标志物GW112在胃癌及结直肠癌等消化道肿瘤中的研究进展 |
| Research Progress of Biomarker GW112 in Gastric Cancer，Colorectal Cancer and Other Gastrointestinal Cancers |
| 投稿时间：2013-01-17 |
| DOI：10.11735/j.issn.1004-0242.2013.11.A014 |
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| 中文关键词: GW112 消化道肿瘤 肿瘤标志物 |
| 英文关键词:GW112 gastrointestinal tumor tumor markers |
| 基金项目:辽宁省大连市科技计划项目(2012E15SF147) |
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| 中文摘要: |
| 摘 要：GW112是近年来发现的嗅觉介导素相关蛋白家族的新成员，在神经发育、细胞间黏附、细胞周期调控及肿瘤发生等多种细胞功能中起重要作用。GW112调节肿瘤细胞增殖、凋亡、黏附，并对关键信号转导通路起调控作用。GW112在消化道肿瘤中异常表达，且在早期胃癌及结直肠癌中呈高度特异性表达，提示其可能成为新的早期诊断胃癌及结直肠癌的靶点基因。 |
| 英文摘要: |
| Abstract: GW112 is a new member of olfactomedin gene family. GW112 plays an important role in a variety of cellular functions，such as neurogenesis，cell adhesion，cell-cycle regulation and tumorigenesis. GW112 also involves in proliferation，apoptosis and adhesion of tumor cells，as well as the regulation of crucial signal transduction pathway. GW112 expresses abnormally in gastrointestinal tumor，especially with a high specificity in the early detection of gastric cancer and colorectal cancer. It suggests that GW112 may become a target gene in the early diagnosis for gastric cancer and colorectal cancer. |
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