| 刘永煜,杨成良,乔 雪.CXCR4基因在食管鳞癌患者术后早期复发转移中表达的研究[J].中国肿瘤,2012,21(4):306-308. |
| CXCR4基因在食管鳞癌患者术后早期复发转移中表达的研究 |
| The Expression of CXCR4 Gene in Esophageal Squamous Cell Carcinoma Patients with Early Postoperative Recurrence and Metastasis |
| 投稿时间：2012-01-02 |
| DOI： |
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| 中文关键词: 食管癌 复发 转移 CXCR4 |
| 英文关键词:esophageal carcinoma recurrence metastasis CXCR4 |
| 基金项目:辽宁省医学高峰建设工程项目（2010079）；辽宁省食管癌重点实验建设专项基金（2011-20）；辽宁省“百千万人才工程”资助项目（2009-390）；辽宁省医学重点专科建设项目（200824） |
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| 中文摘要: |
| 摘 要： ［目的］ 评价CXCR4基因在食管鳞癌术后早期复发转移患者中的表达。［方法］ 选择43例术后早期复发转移食管鳞癌标本、46例术后1年内未发生复发转移食管鳞癌标本和17例正常食管组织标本，应用RT-PCR和Western Blot方法检测标本中CXCR4基因mRNA和蛋白的表达情况。［结果］与术后1年内未发生复发转移食管鳞癌组织和正常食管组织相比，术后早期复发转移食管鳞癌标本CXCR4基因的mRNA和蛋白的表达存在明显上调，差异有统计学意义（P＜0.05）。［结论］ 在食管鳞癌组织中CXCR4基因表达的改变可能与肿瘤复发转移有关。 |
| 英文摘要: |
| Abstract: ［Purpose］ To investigate the expression of CXCR4 gene in esophageal squamous cell patients with early postoperative recurrence and metastasis. ［Methods］ Forty-three tissue samples with early postoperative recurrence and metastasis of esophageal squamous cell carcinoma, 46 tissue samples with postoperative esophageal squamous cell carcinoma without recurrence or metastasis within one year, and 17 samples with normal esophageal tissue were enrolled. mRNA and protein of CXCR4 expressions were detected by RT-PCR and western blot. ［Results］ Compared to postoperative esophageal squamous cell carcinoma without recurrence within one year and normal esophageal tissues, CXCR4 mRNA and protein expression in case with early postoperative recurrence and metastasis of esophageal squamous cell carcinoma tissue samples were up-regulated with statistically different (P<0.05). ［Conclusions］ CXCR4 in esophageal squamous cell carcinoma gene expression changes may be related to tumor recurrence and metastasis. |
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