| 杨 红,覃 胜,王 影.AQP5与非小细胞肺癌临床特征及转移的关系[J].中国肿瘤,2013,22(6):493-496. |
| AQP5与非小细胞肺癌临床特征及转移的关系 |
| Expression of AQP5 in Non-small Cell Lung Cancer: Correlation with Clinicopathological Features and Metastasis |
| 投稿时间：2012-12-18 |
| DOI：10.11735/j.issn.1004-0242.2013.06.2012363 |
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| 中文关键词: AQP5 非小细胞肺癌 转移 |
| 英文关键词:aquaporin5 non-small cell lung cancer metastasis |
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| 中文摘要: |
| 摘 要：［目的］ 探讨AQP5在非小细胞肺癌（NSCLC）原发灶和淋巴结转移灶中的表达及其意义。［方法］ 应用免疫组织化学LSAB法检测94例NSCLC原发灶及51例淋巴结转移灶中AQP5的表达情况。［结果］ AQP5在腺癌中的表达明显高于鳞癌（P=0.002）；在伴有淋巴结转移的NSCLC原发灶中AQP5的表达明显高于不伴有淋巴结转移的原发灶（P=0.024），而转移灶的表达率与原发灶相比差异无统计学意义（P=0.337)；AQP5表达还与NSCLC的TNM分期有关（P=0.027），在Ⅲ期和Ⅳ期中的表达明显高于Ⅰ期和Ⅱ期。AQP5表达与NSCLC患者的生存率无关（P=0.051）。 ［结论］ AQP5 表达与NSCLC的发生发展有关，有望成为研究肺癌发生发展和转移的新靶点。 |
| 英文摘要: |
| Abstract:［Purpose］ To investigate the expression of AQP5 in non-small cell lung cancer and its clinical significance. ［Methods］ AQP5 expression was detected by immunohistochemical staining(LSAB) in 94 cases from NSCLC primary lesion and 51 cases from lymph node metastasis lesion. ［Results］ The expression of AQP5 was higher in patients with adenocarcinoma than that in patients with squamous cell carcinoma(P=0.002). The NSCLC patients with lymph node metastasis showed higher expression of AQP5 than those without(P=0.024)，while no significant difference was observed between primary lesion and metastatic lesion(P=0.337).AQP5 expression correlated with NSCLC TNM staging(P=0.027). The expression in stage Ⅲ and Ⅳ was higher than that in stageⅠ and Ⅱ. AQP5 expression didn’t correlate with differentiation(P=0.904) and survival rate(P=0.051). ［Conclusions］ Expression of AQP5 correlates with carcinogenesis and progress of NSCLC. Therefore，AQP5 might be a promising target for studying the carcinogenesis mechanism of NSCLC. |
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