沈俊俊,潘月芬,卢振产.米氮平治疗大肠癌术后化疗相关焦虑抑郁的疗效观察[J].肿瘤学杂志,2012,18(7):527-529.
米氮平治疗大肠癌术后化疗相关焦虑抑郁的疗效观察
The Effect of Mirtazapine on Chemotherapy-related Anxiety and Depression in Patients with Colorectal Cancer After Surgery
投稿时间:2011-11-04  
DOI:
中文关键词:  米氮平  结直肠肿瘤  焦虑  抑郁  药物疗法
英文关键词:mirtazapine  colorectal neoplasms  anxiety  depression  drug therapy
基金项目:
作者单位
沈俊俊 湖州市中心医院 
潘月芬 湖州市中心医院 
卢振产 湖州市中心医院 
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中文摘要:
      摘 要:[目的] 评价米氮平对大肠癌术后化疗患者焦虑、抑郁的疗效及化疗不良反应的影响。[方法] 根据汉密尔顿焦虑—抑郁量表筛选出56例大肠癌术后化疗后出现焦虑、抑郁的患者,随机分为米氮平组和对照组,观察8周后评定米氮平对化疗患者焦虑、抑郁的疗效及对化疗不良反应的影响。[结果] 米氮平组在化疗后第2、4及8周的焦虑、抑郁量表评分均低于化疗前水平(P<0.05),且明显低于同期对照组(P<0.01)。米氮平组恶心呕吐、失眠等不良反应显著减轻(P<0.05),且米氮平不加重骨髓抑制、肝肾功能损害及神经毒性等化疗不良反应(P>0.05)。[结论] 米氮平干预大肠癌术后化疗伴发焦虑、抑郁障碍患者疗效显著,可有效改善生活质量,减轻化疗引起的不良反应。
英文摘要:
      Abstract: [Purpose] To investigate the effect of mirtazapine on chemotherapy-related anxiety, depression and chemotherapy side effects in patients with colorectal cancer after surgery. [Methods] Fifty-six colorectal cancer patients with chemotherapy-related anxiety and (or) depression screened by the Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale(HAMA) were randomly divided into mirtazapine group and control group. The influences of mirtazapine on chemotherapy-related anxiety,depression and chemotherapy side effects were observed. [Results] The HAMD and HAMA scores in mirtazapine group after 2,4 and 8 weeks of chemotherapy were significantly lower than those before chemotherapy (P<0.05),and lower than those in control group (P<0.01). Nausea,vomiting and insomnia decreased obviously in mirtazapine group(P<0.05). However,mirtazapine didn’t worsen other side effects,such as bone marrow suppression,liver and kidney dysfunction and neurological toxicity (P>0.05). [Conclusion] Mirtazapine can lighten the chemotherapy-related anxiety and depression,improve the quality of life and reduce the occurrence of chemotherapy side effects.
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