| 宋 敏,孔飞飞,蔡海波,等.局部晚期可切除食管癌新辅助治疗研究进展[J].肿瘤学杂志,2026,32(10):886-894. |
| 局部晚期可切除食管癌新辅助治疗研究进展 |
| Advances in Neoadjuvant Therapy for Locally Advanced Resectable Esophageal Cancer |
| 投稿时间：2025-08-18 |
| DOI：10.11735/j.issn.1671-170X.2026.10.B010 |
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| 中文关键词: 食管肿瘤 局部晚期 可切除 新辅助治疗 食管鳞癌 食管腺癌 |
| 英文关键词:esophageal neoplasms locally advanced resectable neoadjuvant therapy esophageal squamous cell carcinoma esophageal adenocarcinoma |
| 基金项目:吴阶平医学基金会（320.6750.2021-16-54） |
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| 中文摘要: |
| 摘 要：在局部晚期食管癌的治疗中，手术治疗占据主导地位。但单一手术治疗效果不佳，患者5年生存率较低。新辅助治疗相比较于单纯手术治疗可显著改善局部晚期食管癌患者的长期生存，因此，新辅助治疗成为局部晚期可切除食管癌的标准治疗。鉴于新辅助治疗模式多样，如何选择最优新辅助治疗模式也是目前研究的热点。全文就局部晚期可切除食管鳞癌及腺癌新辅助治疗的研究进展进行梳理和总结。 |
| 英文摘要: |
| Abstract： Surgery remains the cornerstone of treatment for locally advanced esophageal cancer. However， surgery alone yields suboptimal outcomes， with a low 5-year survival rate. Neoadjuvant therapy has been shown to significantly improve long-term survival compared to surgery alone and has become the standard of care for locally advanced resectable esophageal cancer. Given the diversity of neoadjuvant treatment modalities， identifying the optimal regimen is a key focus of current research. This paper reviews and summarizes recent advances in neoadjuvant therapy for both esophageal squamous cell carcinoma and adenocarcinoma in the locally advanced resectable setting. |
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