| 林美华,单乐瑶,吴志锋,等.人表皮生长因子2低表达乳腺癌诊治现状和临床启示[J].肿瘤学杂志,2026,32(9):795-802. |
| 人表皮生长因子2低表达乳腺癌诊治现状和临床启示 |
| Current Status and Clinical Implications of Diagnosis and Treatment of Human Epidermal Growth Factor Receptor 2 Low Expression Breast Cancer |
| 投稿时间：2026-01-06 |
| DOI：10.11735/j.issn.1671-170X.2026.09.B013 |
|
 |
| 中文关键词: 乳腺肿瘤 人表皮生长因子受体2 低表达 免疫组织化学 抗体药物偶联物 |
| 英文关键词:breast neoplasms human epidermal growth factor receptor 2 low expression immunohistochemistry antibody-drug conjugates |
| 基金项目:新疆生产建设兵团科技项目（2025DA068） |
|
| 摘要点击次数: 10 |
| 全文下载次数: 0 |
| 中文摘要: |
| 摘 要：根据人表皮生长因子受体2（human epidermal growth factor receptor 2，HER2）表达水平，传统上将乳腺癌分为HER2阳性和HER2阴性两类。近年来，研究发现部分传统HER2阴性的患者存在HER2低表达的情况，即免疫组织化学评分1+或2+且荧光原位杂交无HER2基因扩增。这类患者以往未能从HER2靶向治疗中获益，但抗体药物偶联物，如曲妥珠单抗德鲁替康的出现为其提供了新的治疗选择。全文围绕HER2低表达乳腺癌的概念、诊断标准和检测方法一致性问题，系统总结其临床病理特征、预后意义以及当前针对HER2低表达乳腺癌患者的治疗研究进展，并提出未来应在标准化检测、临床疗效评估和真实世界研究等方面加强探索，为临床决策提供科学依据。 |
| 英文摘要: |
| Abstract： Traditionally， breast cancer has been classified into human epidermal growth factor receptor 2 (HER2)-positive and HER2-negative subtypes according to HER2 expression. In recent years， studies have identified a subgroup of patients previously categorized as HER2-negative who exhibit HER2-low expression， defined as an immunohistochemistry(IHC) score of 1+ or 2+ but without HER2 gene amplification as detected by fluorescence in situ hybridization. Previously， this population did not benefit from conventional anti-HER2 targeted therapies. However， the development of antibody-drug conjugates， particularly trastuzumab deruxtecan (T-DXd)， has provided new therapeutic options for patients with HER2-low breast cancer. This paper reviews the evolving concept of HER2-low breast cancer， its diagnostic criteria， and issues related to testing consistency， and systematically summarizes its clinicopathological characteristics， prognostic significance， and current therapeutic advances. Furthermore， future directions including test standardization， optimization of clinical efficacy assessment， and real-world studies are discussed， aiming to provide evidence-based support for precision clinical decision-making. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |