| 赖碎丽,陈禹呈,徐岚静,等.浙江省肿瘤登记地区喉癌2021年流行特征及2000—2021年趋势分析[J].肿瘤学杂志,2026,32(9):760-767. |
| 浙江省肿瘤登记地区喉癌2021年流行特征及2000—2021年趋势分析 |
| Incidence and Mortality of Laryngeal Cancer in 2021 and Trends from 2000 to 2021 in Zhejiang Province Cancer Registration Areas |
| 投稿时间：2026-07-23 |
| DOI：10.11735/j.issn.1671-170X.2026.09.B008 |
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| 中文关键词: 喉肿瘤 发病率 死亡率 肿瘤登记 浙江 |
| 英文关键词:laryngeal neoplams incidence mortality cancer registration Zhejiang |
| 基金项目:浙江省疾病预防控制科技计划项目（2026JKY323） |
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| 中文摘要: |
| 摘 要：［目的］ 分析2000—2021年浙江省肿瘤登记地区喉癌的流行特征及趋势，为制定喉癌防控策略提供依据。［方法］ 收集2000—2021年浙江省各肿瘤登记处上报的喉癌发病与死亡数据，经浙江省肿瘤防治办公室审核整理，计算粗发病/死亡率、中国标准人口标化率（中标率）、世界标准人口标化率（世标率）、0~74岁累积发病/死亡率和35~64截缩发病/死亡率。采用Joinpoint回归模型计算平均年度变化百分比（average annual percentage change，AAPC）及其95%置信区间（confidence interval，CI）。［结果］ 2021年浙江省肿瘤登记地区喉癌粗发病率为2.59/10万，中标发病率为1.20/10万，世标发病率为1.23/10万，喉癌粗死亡率为0.88/10万，中标死亡率为0.36/10万，世标死亡率为0.36/10万。2000—2021年浙江省肿瘤登记地区喉癌平均粗发病率为1.97/10万，中标发病率为1.09/10万，世标发病率为1.12/10万；0~74岁累积发病率为0.14%，35~64岁截缩发病率为1.95/10万；喉癌粗死亡率为0.74/10万，中标死亡率为0.38/10万，世标死亡率为0.38/10万；0~74岁累积死亡率为0.04%，35~64岁截缩死亡率为0.44/10万。喉癌发病率在40岁前处于较低水平，50岁后快速上升，总体和男性发病率均于75~79岁年龄组达峰值，女性则于80~84岁年龄组达峰值。2000—2021年喉癌中标发病率整体变化平稳，女性中标发病率呈显著性下降趋势（AAPC=-4.66%，95%CI：-6.79%~ -2.30%，P<0.001），而农村地区发病率呈显著性上升趋势（AAPC=4.48%，95%CI：2.50%~6.56%，P<0.001）。喉癌中标死亡率呈上升趋势（AAPC=3.16%，95%CI：0.19%~5.40%，P=0.046），男性（AAPC=2.20%，95%CI：0.28%~4.24%，P=0.026）、女性（AAPC=31.32%，95%CI：8.40%~46.82%，P=0.012）中标死亡率均呈显著性上升趋势，农村地区中标死亡率也呈显著性上升趋势（AAPC=4.21%，95%CI：1.90%~6.70%，P=0.001）。［结论］ 2000—2021年浙江省肿瘤登记地区喉癌发病率与死亡率总体处于较低水平，但中标死亡率呈上升趋势。男性及85岁以上人群为死亡风险较高的核心群体。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the epidemiological characteristics and trends of laryngeal cancer in Zhejiang Province cancer registration areas from 2000 to 2021， and to provide a basis for developing prevention and control strategies. ［Methods］ Data on laryngeal cancer new cases and deaths reported by Zhejiang Province cancer registries from 2000 to 2021 were collected， reviewed by Zhejiang Provincial Office for Cancer Prevention and Control. The crude incidence/mortality， age-standardized incidence/mortality rates by Chinese population(ASIRC/ASMRC) and by world standard population (ASIRW/ASMRW)， 0-74 years old cumulative rates， and 35-64 years old truncated rates were calculated. Joinpoint regression models was used to estimate the average annual percentage change (AAPC) and 95% confidence interval (CI). ［Results］ In 2021， the crude incidence of laryngeal cancer in Zhejiang Province cancer registration areas was 2.59/105， the ASIRC was 1.20/105， and the ASIRW was 1.23/105. In 2021, the crude mortality for laryngeal cancer in Zhejiang Province cancer registration areas was 0.88/105， the ASMRC was 0.36/105， and the ASMRW was 0.36/105. From 2000 to 2021， the average crude incidence of laryngeal cancer in Zhejiang Province cancer registration areas was 1.97/105， the ASIRC was 1.09/105， and the ASIRW was 1.12/105. The 0-74 years old cumulative incidence was 0.14%， and the 35-64 years old truncated incidence was 1.95/105. The crude mortality for laryngeal cancer was 0.74/105， with the ASMRC of 0.38/105 and the ASMRW 0.38/105. The 0-74 years old cumulative mortality was 0.04%， and the 35-64 years old truncated mortality was 0.44/105. The incidence of laryngeal cancer remains at a relatively low level before age 40 years old and rose rapidly after age 50 years old. Both the overall incidence and the incidence in males peaked in the age group of 75-79 years old ， while in females， it peaked in the age group of 80-84 years old. From 2000 to 2021， the ASIRC of laryngeal cancer remained generally stable. The ASIRC among female showed a significant downward trend (AAPC=-4.66%， 95%CI：-6.79%--2.30%， P<0.001)， whereas in rural areas， it showed a significant upward trend (AAPC=4.48%， 95%CI：2.50%-6.56%， P<0.001). The ASMRC for laryngeal cancer showed an upward trend (AAPC=3.16%， 95%CI：0.19%-5.40%， P=0.046)， and ASMRC among male (AAPC=2.20%， 95%CI：0.28%-4.24%， P=0.026)， female (AAPC=31.32%，95%CI：8.40%-46.82%，P=0.012) and rural areas (AAPC=4.21%，95%CI：1.90%-6.70%， P=0.001) also showed an upward trend. ［Conclusion］ From 2000 to 2021， the incidence and mortality of laryngeal cancer in Zhejiang Province cancer registration areas remained generally low overall； however， the ASMRC showed an upward trend， with male and individuals aged over 85 years old constituting the core groups at highest risk of death. |
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