| 李本和,徐 裴,张 彩,等.浙江省肿瘤登记地区白血病2021年流行特征及2000—2021年趋势分析[J].肿瘤学杂志,2026,32(9):753-759. |
| 浙江省肿瘤登记地区白血病2021年流行特征及2000—2021年趋势分析 |
| Incidence and Mortality of Leukemia in 2021 and Trends from 2000 to 2021 in Zhejiang Province Cancer Registration Areas |
| 投稿时间：2026-07-13 |
| DOI：10.11735/j.issn.1671-170X.2026.09.B007 |
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| 中文关键词: 白血病 发病率 死亡率 肿瘤登记 浙江 |
| 英文关键词:leukemia incidence mortality cancer registration Zhejiang |
| 基金项目:国家自然科学基金（82300180）；浙江省自然科学基金（LBY23H080006） |
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| 中文摘要: |
| 摘 要：［目的］ 分析浙江省肿瘤登记地区2021年白血病发病、死亡流行特征及2000—2021年趋势变化。［方法］ 收集浙江省肿瘤登记地区2000—2021年的白血病发病、死亡数据、人口数据，计算粗发病率与死亡率、年龄别发病率与死亡率、中国标准人口标化率（简称中标率）、世界标准人口标化率（简称世标率）及平均年度变化百分比（average annual percentage change，AAPC），并采用Joinpoint回归分析白血病的发病和死亡变化趋势。［结果］ 2021年浙江省肿瘤登记地区白血病粗发病率为10.19/10万，中标发病率为6.50/10万；粗死亡率为5.06/10万，中标死亡率为2.53/10万。男性白血病发病与死亡水平均高于女性，发病峰值年龄为80～84岁组，死亡峰值年龄为≥85岁组。2000—2021年浙江省白血病粗发病率（AAPC=3.27%，P＜0.001）及中标发病率（AAPC=1.34%，P＜0.001）均呈上升趋势，男性粗发病率与中标发病率（AAPC=3.61%、1.68%）的增长幅度均高于女性（AAPC=2.90%、0.95%），农村地区粗发病率和中标发病率（AAPC=7.48%，5.59%）的增长幅度均高于城市地区（AAPC=1.40%，0.04%），城市地区中标发病率上升趋势无统计学意义。2000—2021年浙江省白血病粗死亡率（AAPC=4.79%，P＜0.001）及中标死亡率（AAPC=2.26%，P＜0.05）也呈上升趋势，男、女性粗死亡率与男性中标死亡率与总体一致呈上升趋势，女性中标死亡率呈下降趋势无统计学意义，城市地区粗死亡率与中标死亡率均呈上升趋势，农村地区粗死亡率呈上升趋势，而中标死亡率呈下降趋势，城乡趋势变化有统计学意义。［结论］ 浙江省肿瘤登记地区白血病发病和死亡水平2000—2021年呈持续上升趋势。婴幼儿及老年人群为重点关注对象，应加强基于高危人群的健康宣教及暴露风险防控，提高早诊早治率。 |
| 英文摘要: |
| Abstract： ［Objective］ To analyze the incidence and mortality of leukemia in Zhejiang Province cancer registration areas in 2021 and their trends from 2000 to 2021. ［Methods］ Data on leukemia new cases， deaths， and corresponding population statistics were collected from Zhejiang Province cancer registries from 2000 to 2021. Crude incidence /mortality， age-specific incidence /mortality， age-standardized incidence/mortality rates by Chinese standard population (ASIRC/ASMRC) and by world standard population (ASIRW/ASMRW) were calculated. Joinpoint regression was used to estimate the average annual percentage change(AAPC) with 95% confidence intervals (CI). ［Results］ In 2021， the crude incidence of leukemia was 10.19/105， with an ASIRC of 6.50/105 in Zhejiang Province cancer registration areas， and the crude mortality rate was 5.06/105， with an ASMRC of 2.53/105. Both incidence and mortality of leukemia were higher in males than in females. The peak incidence occurred in the age group of 80-84 years old， while the highest mortality was in those aged ≥85 years old. From 2000 to 2021， the crude incidence (AAPC=3.27%， P<0.001) and ASIRC (AAPC=1.34%， P<0.001) showed significant upward trends. The increases were greater in males (crude incidence： 3.61%， ASIRC： 1.68%) than that in females (2.90%， 0.95%)， and greater in rural areas (crude incidence： 7.48%； ASIRC： 5.59%) than that in urban areas (1.40%， 0.04%)， although the upward trend in urban ASIRC was not statistically significant. Over the same period， the crude mortality (AAPC=4.79%， P<0.001) and ASMRC(AAPC=2.26%， P<0.05) also increased. The crude and ASMRC in males both increased， while the crude mortality in females increased but the decline in ASMRC was not significant. In urban areas， both crude mortality and ASMRC increased， while in rural areas， crude mortality increased but ASMRC decreased. The urban-rural differences in these trends were statistically significant. ［Conclusion］ The incidence and mortality of leukemia in Zhejiang Province cancer registration areas have been continuously rising from 2000 to 2021. Infants， young children， and the elderly should be prioritized， and enhanced health education and exposure risk control targeting high-risk populations are warranted. |
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