| 彭二磊,沈红伟,张一璐,等.浙江省肿瘤登记地区骨恶性肿瘤2021年流行特征及2000—2021年趋势分析[J].肿瘤学杂志,2026,32(9):748-752. |
| 浙江省肿瘤登记地区骨恶性肿瘤2021年流行特征及2000—2021年趋势分析 |
| Incidence and Mortality of Malignant Bone Tumors in 2021 and Trends from 2000 to 2021 in Zhejiang Province Cancer Registration Areas |
| 投稿时间：2026-06-12 |
| DOI：10.11735/j.issn.1671-170X.2026.09.B006 |
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| 中文关键词: 骨恶性肿瘤 发病率 死亡率 肿瘤登记 浙江 |
| 英文关键词:malignant bone tumors incidence mortality cancer registration Zhejiang |
| 基金项目:浙江省疾病预防控制科技计划项目（2025JK099） |
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| 中文摘要: |
| 摘 要：［目的］ 分析浙江省肿瘤登记地区2021年骨恶性肿瘤发病和死亡特征以及2000—2021年变化趋势。［方法］ 收集并整理浙江省肿瘤登记处上报的2000—2021年骨恶性肿瘤发病和死亡数据，计算骨恶性肿瘤粗发病率和粗死亡率、中国标准人口标化发病率（简称中标发病率）等指标。采用Joinpoint回归模型计算骨恶性肿瘤标化发病率和标化死亡率的平均年度变化百分比（average annual percentage change，AAPC）及95%置信区间（confidence interval，CI），并分析变化趋势。［结果］ 2021年浙江省肿瘤登记地区骨恶性肿瘤的粗发病率为1.13/10万，中标发病率为0.80/10万；粗死亡率为 0.65/10万，中标死亡率为0.37/10万。男性中标发病率（0.93/10万）和中标死亡率（0.45/10万）均高于女性（0.69/10万、0.28/10万）；城市地区中标发病率（0.75/10万）略低于农村地区（0.88/10万），中标死亡率（0.38/10万）略高于农村地区（0.35/10万）。骨恶性肿瘤的粗发病率和粗死亡率总体随年龄增长呈上升趋势，60岁以后快速上升，80岁以后达到高峰。2000—2021年浙江省肿瘤登记地区骨恶性肿瘤总体中标发病率和中标死亡率均呈明显下降趋势（中标发病率：AAPC=-6.45%，95%CI：-7.68%~-5.11%，P＜0.001；中标死亡率：AAPC=-5.08%，95%CI：-6.29%~ -3.81%，P＜0.001），其中男性、女性、城市地区的中标发病率与中标死亡率均呈下降趋势，而农村地区中标发病率变化无统计学意义。［结论］ 浙江省骨恶性肿瘤负担总体呈持续下降趋势，城乡间发病和死亡差异不显著。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the incidence and mortality of malignant bone tumors in Zhejiang Province cancer registration areas in 2021 and their trends from 2000 to 2021. ［Methods］ New cases and deaths data for malignant bone tumors(2000—2021) were collected and compiled from Zhejiang Province cancer registries. Crude rates， age-standardized incidence rates by Chinese standard population (ASIRC)， age-standardized mortality rates by Chinese standard population (ASMRC) and other indicators were calculated. Joinpoint regression was applied to estimate the average annual percentage change (AAPC) and its 95% confidence interval (CI) for ASIRC and ASMRC， and to evaluate long-term trends. ［Results］ In 2021， the crude incidence was 1.13/105 and the ASIRC was 0.80/105， the crude mortality was 0.65/105 and the ASMRC was 0.37/105. Both ASIRC (0.93/105) and ASMRC (0.45/105) were higher in males than in females (0.69/105 and 0.28/105， respectively). The urban areas ASIRC (0.75/105) was slightly lower than the rural areas (0.88/105)， whereas the urban areas ASMRC(0.38/105) was marginally higher than the rural areas (0.35/105). Crude rates generally increased with age， rising sharply after 60 years old and peaking after 80 years old. Over the entire study period from 2000 to 2021， both overall ASIRC and ASMRC declined significantly (ASIRC： AAPC=-6.45%， 95%CI：-7.68%--5.11%， P<0.001； ASMRC： AAPC=-5.08%， 95%CI：-6.29%--3.81%， P<0.001). Stratified analyses showed that both ASIRC and ASMRC were significant downward trends in males， females， and urban populations， while the decrease in rural areas ASIRC was not statistically significant. ［Conclusion］ The disease burden of malignant bone tumors in Zhejiang Province has been continuously decreasing， and no substantial urban-rural disparities in incidence or mortality were observed. |
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