张光欣,凤思苑,李辉章,等.浙江省肿瘤登记地区膀胱癌2021年流行特征及2000—2021年趋势分析[J].肿瘤学杂志,2026,32(9):741-747.
浙江省肿瘤登记地区膀胱癌2021年流行特征及2000—2021年趋势分析
Incidence and Mortality of Bladder Cancer in 2021 and Trends from 2000 to 2021 in Zhejiang Province Cancer Registration Areas
投稿时间:2026-06-30  
DOI:10.11735/j.issn.1671-170X.2026.09.B005
中文关键词:  膀胱肿瘤  发病率  死亡率  肿瘤登记  浙江
英文关键词:bladder neoplasms  incidence  mortality  cancer registration  Zhejiang
基金项目:
作者单位
张光欣 诸暨市疾病预防控制中心 
凤思苑 诸暨市疾病预防控制中心 
李辉章 浙江省肿瘤医院,浙江省肿瘤防治办公室 
何 亮 诸暨市疾病预防控制中心 
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中文摘要:
      摘 要:[目的] 分析浙江省肿瘤登记地区2021年膀胱癌发病、死亡情况以及2000—2021年变化趋势。 [方法] 收集整理浙江省肿瘤登记处提交的2000—2021年膀胱癌发病、死亡登记数据;人口数据来源于各登记地区公安部门户籍管理系统或统计部门年鉴数据,分别计算膀胱癌粗发病率和粗死亡率、中国标准人口标化率(简称中标率)、世界标准人口标化率(简称世标率)指标。采用Joinpoint软件计算年度变化百分比(annual percentage change,APC)和平均年度变化百分比(average annual percentage change,AAPC)及其95%置信区间(confidence interval,CI)。[结果] 2021年浙江省肿瘤登记地区膀胱癌粗发病率为8.65/10 万,中标发病率为3.82/10万,世标发病率为3.81/10万;膀胱癌粗死亡率为2.95/10万,中标死亡率为 1.01/10万,世标死亡率为1.04/10万。男性粗发病率和粗死亡率分别是女性的4.80和4.40倍。膀胱癌粗发病率和粗死亡率高峰均在85岁及以上年龄组,且出现标化年龄别发病构成比高峰左移。2000—2021年浙江省膀胱癌全人群中标发病率和中标死亡率趋势变化无统计学意义(P均>0.05)。女性膀胱癌中标发病率和中标死亡率均呈下降趋势,中标发病率的AAPC分别为-2.10%(95%CI:-2.95%~-1.22%,P<0.05),中标死亡率AAPC为-3.34%(95%CI:-4.24%~-1.44%,P<0.05)。 城市地区中标发病率呈下降趋势,AAPC= -1.14%(95%CI:-1.58%~-0.59%,P<0.05);农村地区中标发病率呈上升趋势AAPC=2.73%(95%CI:1.73%~3.79%,P<0.05 )。[结论] 浙江省肿瘤登记地区膀胱癌流行趋势存在性别、地区和年龄差异,且出现发病年龄前移的趋势。
英文摘要:
      Abstract: [Objective] To investigate the incidence and mortality of bladder cancer in Zhejiang Province cancer registration areas in 2021 and their trends from 2000 to 2021. [Methods] Data on bladder cancer new cases and deaths (2000—2021) were collected from Zhejiang Province cancer registries. Crude incidence and crude mortality, age-standardized incidence/mortality rates by Chinese standard population (ASIRC/ASMRC) and by world standard population(ASIRW/ASMRW) were calculated. Joinpoint regression was used to estimate annual percentage changes (APC) and average annual percentage changes (AAPC) with 95% confidence intervals(CI). [Results] In 2021, the crude incidence was 8.65/105, with ASIRC of 3.82/105 and ASIRW of 3.81/105 in Zhejiang Province cancer registration areas. The crude mortality was 2.95/105, with ASMRC of 1.01/105 and ASMRW of 1.04/105. The crude incidence and mortality in males were 4.80 and 4.40 times those in females, respectively. Both incidence and mortality peaked in the age group of 85 years old and above, and the peak of the age-standardized incidence composition ratio shifted leftward over time. From 2000 to 2021, the overall ASIRC and ASMRC did not show statistically significant changes (both P>0.05). In females, both ASIRC and ASMRC declined significantly, with AAPC of -2.10% (95%CI: -2.95%--1.22%) and -3.34% (95%CI: -4.24%--1.44%), respectively (both P<0.05). Urban areas experienced a significant decrease in ASIRC (AAPC=-1.14%, 95%CI: -1.58%--0.59%, P<0.05), whereas rural areas showed a significant increase (AAPC=2.73%, 95%CI: 1.73%-3.79%, P<0.05). [Conclusion] The Incidence and mortality of bladder cancer in Zhejiang Province cancer registration areas vary by sex, region, and age, with a tendency toward earlier age at onset.
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