| 陈 捷,孙力涵,翁琼莉,等.浙江省肿瘤登记地区胰腺癌2021年流行特征及2000—2021年趋势分析[J].肿瘤学杂志,2026,32(9):724-732. |
| 浙江省肿瘤登记地区胰腺癌2021年流行特征及2000—2021年趋势分析 |
| Incidence and Mortality of Pancreatic Cancer in 2021 and Trends from 2000 to 2021 in Zhejiang Province Cancer Registration Areas |
| 投稿时间：2026-07-22 |
| DOI：10.11735/j.issn.1671-170X.2026.09.B003 |
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| 中文关键词: 胰腺肿瘤 发病率 死亡率 肿瘤登记 浙江 |
| 英文关键词:pancreas neoplasms incidence mortality cancer registration Zhejiang |
| 基金项目:浙江省疾病预防控制科技计划（2026JKZ068） |
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| 中文摘要: |
| 摘 要：［目的］ 分析浙江省肿瘤登记地区胰腺癌2021年发病、死亡流行特征及2000—2021年趋势。［方法］ 提取浙江省肿瘤登记处上报的2000—2021年肿瘤登记资料中《国际疾病分类》第10版编码为C25的胰腺癌发病、死亡资料和人口数据，计算合计、性别、年龄别和城乡地区发病（死亡）粗率、中国标准人口标化发病（死亡）率［简称中标发病（死亡）率）］、世界标准人口标化发病（死亡）率［简称世标发病（死亡）率）］以及年度变化百分比（annual percentage change，APC）、平均年度变化百分比（average annual percentage change，AAPC）及95%置信区间（confidence interval，CI）等指标。［结果］ 2021年浙江省肿瘤登记地区胰腺癌粗发病率为13.41/10万，中标发病率为5.98/10万，世标发病率为 6.88/10万，发病年龄高峰为80～84岁组。男性中标发病率是女性的1.44倍（7.08/10万 vs 4.92/10万），城市地区中标发病率是农村地区的1.08倍（6.16/10万 vs 5.69/10万）。2021年胰腺癌粗死亡率为11.88/10万，中标死亡率为5.04/10万，世标死亡率为5.93/10万，死亡年龄高峰为85岁及以上年龄组。男性中标死亡率是女性的1.51倍（6.09/10万 vs 4.04/10万），城市地区中标死亡率是农村地区1.08倍（5.20/10万 vs 4.80/10万）。2000—2021年浙江省肿瘤登记地区胰腺癌粗发病率呈上升趋势，AAPC为2.97%（95%CI：2.42%～3.53%，P＜0.01），但中标发病率的上升趋势无统计学意义，AAPC为0.43%（95%CI：-0.03%～0.92%，P=0.07）。胰腺癌粗死亡率和中标死亡率均呈上升趋势，AAPC分别为3.42%（95%CI：2.69%～4.41%，P＜0.01）和0.75%（95%CI：0.21%～1.35%，P=0.02）。［结论］ 浙江省肿瘤登记地区胰腺癌死亡率呈上升趋势，发病与死亡人群主要集中在40岁以后年龄组，应着力控制危险因素流行，关注重点人群，强化健康教育，倡导健康生活方式，降低胰腺癌疾病负担。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the incidence and mortality of pancreatic cancer in Zhejiang Province cancer registration areas in 2021 and trends from 2000 to 2021. ［Methods］ Data on pancreatic cancer (ICD-10： C25) new cases， deaths， and corresponding population statistics from 2000 to 2021 were extracted from Zhejiang Province cancer registries. Crude incidence and mortality rates， age-standardized incidence/mortality rates by Chinese standard population (ASIRC/ASMRC) and by world standard population(ASMIW/ASMRW)， as well as annual percentage changes (APC) and average annual percentage changes (AAPC) with 95% confidence intervals (CI) were calculated and by sex， age group， and urban/rural areas. ［Results］ In 2021， the crude incidence was 13.41/105， with an ASIRC of 5.98/105 and an ASIRW of 6.88/105， the incidence peaked in the age group of 80-84 years old. The male ASIRC (7.08/105) was 1.44 times that in females (4.92/105)， and the urban areas ASIRC (6.16/105) was 1.08 times that in rural areas (5.69/105). The crude mortality was 11.88/105， with an ASMRC of 5.04/105 and an ASMRW of 5.93/105， mortality peaked in those aged ≥85 years old. ASMRC(6.09/105) in males was 1.51 times that in females (4.04/105)， and ASMRC(5.20/105) in urban areas was 1.08 times that in rural areas (4.80/105). From 2000 to 2021， the crude incidence increased significantly (AAPC=2.97%， 95%CI： 2.42%-3.53%， P<0.01)， whereas the ASIRC did not change significantly (AAPC=0.43%， 95%CI： -0.03%-0.92%， P=0.07). Both crude mortality (AAPC=3.42%， 95%CI： 2.69%-4.41%， P<0.01) and ASMRC(AAPC=0.75%， 95%CI： 0.21%-1.35%， P=0.02) showed significant increasing trends. ［Conclusion］ Pancreatic cancer mortality in Zhejiang Province cancer registration areas has been rising， with incidence and mortality concentrated in individuals aged 40 years old and above. Targeted interventions focusing on risk factor control， enhanced surveillance of high-risk populations， health education， and promotion of healthy lifestyles are warranted to reduce the disease burden of pancreatic cancer. |
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