| 陈 桥,张海俊,陈星潼,等.新疆石河子地区2022—2024年上消化道癌早诊筛查结果分析[J].肿瘤学杂志,2026,32(7):534-538. |
| 新疆石河子地区2022—2024年上消化道癌早诊筛查结果分析 |
| Screening Outcomes for Early Diagnosis of Upper Gastrointestinal Cancer from 2022 to 2024 in Shihezi Area， Xinjiang |
| 投稿时间：2025-10-16 |
| DOI：10.11735/j.issn.1671-170X.2026.07.B002 |
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| 中文关键词: 上消化道肿瘤 肿瘤筛查 高级别上皮内瘤变 新疆 |
| 英文关键词:upper gastrointestinal neoplasms cancer screening high-grade intraepithelial neoplasia Xinjiang |
| 基金项目:新疆兵团基础研究类重点项目（2025DA017）；新疆兵团重点领域科技攻关项目（2023AB058）；国家自然科学基金（82460597）；石河子大学基础研究计划项目（MSPY202407）；新疆兵团指导性科技计划项目（2023ZD027）；大学生研究训练计划项目（SRP2025069） |
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| 中文摘要: |
| 摘 要：［目的］ 分析2022—2024年新疆石河子地区上消化道癌早诊筛查情况，掌握筛查结果的变化趋势。［方法］ 收集2022—2024年石河子地区上消化道癌人群筛查的相关数据，统计内镜筛查及病理检查结果。 阳性病变包括食管、贲门和胃的高级别上皮内瘤变及以上病变。计算上消化道癌筛查的阳性病变检出率和早诊率。采用χ2检验分析方法分析不同年份、部位、性别及年龄组阳性病变检出率和早诊率的差异。［结果］ 2022—2024年共完成8 274人内镜筛查，其中5 578人接受病理检查，共检出阳性病变102例，总检出率为1.23%（102/8 274）；其中早期病例68例，上消化道癌筛查的早诊率为66.67%（68/102）。 2022年、2023年和2024年阳性病变检出率分别为1.12%（29/2 595）、1.07%（27/2 527）和1.46%（46/3 152）；早诊率分别为62.07%（18/29）、66.67%（18/27）和69.57%（32/46），不同年度间阳性病变检出率和早诊率差异均无统计学意义（P均>0.05）。食管、贲门、胃阳性病例数分别为15例、12例和75例，早诊率分别为66.67%（10/15）、58.33%(7/12)和68.00%（51/75）。男性阳性病变的检出率显著性高于女性（2.05% vs 0.57%, P<0.001）；男、女性早诊率分别为69.74%（53/76）和57.69%（15/26）。阳性病变的检出率随年龄增长呈上升趋势，其中65～69岁年龄组检出率最高（3.41%）。早诊率以60～64岁组最高（86.36%），其次为55～59岁组（66.67%）和65～69岁组（63.64%）。［结论］ 2022—2024年石河子地区上消化道癌总体阳性病变检出率及早诊率呈逐步提高趋势，尤其是2024年提升明显。男性、老年人群（65～69岁）是今后上消化道癌筛查工作的重点。 |
| 英文摘要: |
| Abstract： ［Objective］ To analyze the results of early diagnosis screening for upper gastrointestinal cancer from 2022 to 2024 in the Shihezi Area， Xinjiang， and to identify temporal trends in screening outcomes. ［Methods］ Data from population-based upper gastrointestinal cancer screening in the Shihezi area during 2022—2024 were collected. Endoscopic and pathological findings were statistically analyzed. Positive lesions were defined as high-grade intraepithelial neoplasia or more advanced lesions in the esophagus， cardia， or stomach. The detection rate of positive lesions and the early diagnosis rate were calculated. The chi-square test was used to compare differences in detection and early-diagnosis rates by year， anatomical site， sex， and age group. ［Results］ A total of 8 274 individuals underwent endoscopic screening during 2022—2024， of whom 5 578 received pathological examination. Overall， 102 positive lesions were identified， yielding a total detection rate of 1.23% (102/8 274)； 68 of these were early-stage cases， corresponding to an early diagnosis rate of 66.67% (68/102). The annual detection rates in 2022， 2023， and 2024 were 1.12% (29/2 595)， 1.07% (27/2 527)， and 1.46% (46/3 152)， respectively， with corresponding early diagnosis rates of 62.07% (18/29)， 66.67% (18/27)， and 69.57% (32/46)； no significant difference was observed across years (both P>0.05). Positive cases in the esophagus， cardia， and stomach numbered 15， 12， and 75， with early diagnosis rates of 66.67% (10/15)， 58.33% (7/12)， and 68.00%(51/75)， respectively. The detection rate was significantly higher in males than that in females (2.05% vs 0.57%， P<0.001)； early diagnosis rates were 69.74% (53/76) in males and 57.69% (15/26) in females. The detection rate increased with age， peaking at 3.41% in the 65-69 years old group. The highest early diagnosis rate was observed in the 60-64 years old group (86.36%)， followed by 55-59 years old group (66.67%) and 65-69 years old group (63.64%). ［Conclusion］ The overall detection rate of positive lesions and the early diagnosis rate for upper gastrointestinal cancer showed a gradual upward trend in the Shihezi Area from 2022 to 2024， with a notable improvement in 2024. Males and elderly individuals(65-69 years old) should be prioritized in future screening programs. |
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