| 孙 晨,何 飞,耿 佳,等.江苏省盐城市盐都区2013—2024年上消化道癌筛查结果分析[J].肿瘤学杂志,2026,32(7):527-533. |
| 江苏省盐城市盐都区2013—2024年上消化道癌筛查结果分析 |
| Screening Outcomes for Upper Gastrointestinal Cancer in Yandu District， Yancheng City， Jiangsu Province from 2013 to 2024 |
| 投稿时间：2026-05-12 |
| DOI：10.11735/j.issn.1671-170X.2026.07.B001 |
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| 中文关键词: 上消化道肿瘤 肿瘤筛查 高危人群 江苏 |
| 英文关键词:upper gastrointestinal neoplsams cancer screening high-risk population Jiangsu |
| 基金项目:中国科学院A类先导项目（XDA0580000）；上海市分子影像学重点实验室建设项目（18DZ2260400） |
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| 中文摘要: |
| 摘 要：［目的］ 分析年江苏省盐城市盐都区上消化道癌筛查情况及防控效果。［方法］ 研究对象来自2013—2024年盐城市盐都区参加淮河流域癌症早诊早治项目的上消化道癌筛查人群，分析高危人群率、胃镜检查依从率。阳性病变包括高级别上皮内瘤变（重度异型增生）、早期癌和进展期癌，分析阳性病变检出率及早诊率。采用Joinpoint回归模型计算平均年度变化百分比（average annual percentage change，AAPC）和95%置信区间（confidence interval，CI）分析年度变化趋势。［结果］ 2013—2024年盐城市盐都区共纳入筛查对象64 047人，上消化道癌高危人群率为49.10%，胃镜检查依从率为62.42%，不同特征人群的高危人群率、依从率差异均具有统计学意义（P均<0.01）。阳性病变总体检出率为0.92%。2013—2024年阳性病变检出率呈上升趋势（AAPC=7.35%，95%CI：0.71%~14.34%，P=0.031）；2013—2024年阳性病变早诊率为58.56%，年度变化无统计学差异（AAPC=-2.39%，95%CI：-10.09%~6.31%，P=0.430）。胃癌与食管阳性病变的检出率均呈男性高于女性以及随年龄递增的特征（P均<0.001）。［结论］ 盐城市盐都区上消化道癌筛查高危人群率和胃镜检查依从率均处于省内外中等偏上水平。建议重点针对男性、高龄人群优化筛查与健康管理全流程，依托医防融合体系强化癌症综合防控效能，进一步降低上消化道癌疾病负担。 |
| 英文摘要: |
| Abstract：［Objective］ To evaluate the screening outcomes and effectiveness of upper gastrointestinal cancer (UGIC) prevention and control in Yandu District， Yancheng City， Jiangsu Province. ［Methods］ Data were derived from residents who participated in the UGIC screening program of the Huaihe River Basin Cancer Early Diagnosis and Treatment Project in Yandu District during 2013—2024. The high-risk population rate and gastroscopy compliance rate were calculated. Positive lesions were defined as high-grade intraepithelial neoplasia (severe dysplasia)， early-stage cancer， or advanced cancer. The detection rate of positive lesions and the early diagnosis rate were analyzed. Joinpoint regression was used to estimate the average annual percentage change (AAPC) with 95% confidence interval (CI) for temporal trends. ［Results］ A total of 64 047 individuals were enrolled in the screening program. The high-risk population rate was 49.10%， and the gastroscopy compliance rate was 62.42%. Significant differences in both rates were observed across subgroups defined by demographic and lifestyle characteristics (all P<0.01). The overall detection rate of positive lesions was 0.92%， with a significant upward trend from 2013 to 2024 (AAPC=7.35%， 95%CI： 0.71%-14.34%， P=0.031). The early diagnosis rate was 58.56% over the study period， with no significant annual change (AAPC=-2.39%， 95%CI： -10.09%-6.31%， P=0.430). Detection rates for both gastric and esophageal positive lesions were significantly higher in males than those in females and increased with age (both P<0.001). ［Conclusion］ The high-risk population rate and gastroscopy compliance rate in Yandu District are above the provincial and national averages. Targeted optimization of screening and health management for males and older adults is recommended. Strengthening integrated medical-preventive services could further enhance comprehensive cancer control and reduce the burden of UGIC. |
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