| 张 婷,李向向,杨妹霞,等.蛹虫草活性成分抗肿瘤分子机制研究进展[J].肿瘤学杂志,2026,32(6):511-521. |
| 蛹虫草活性成分抗肿瘤分子机制研究进展 |
| Research Progress on the Molecular Mechanisms Underlying the Antitumor Effects of Bioactive Components from Cordyceps Militaris |
| 投稿时间：2025-11-17 |
| DOI：10.11735/j.issn.1671-170X.2026.06.B009 |
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| 中文关键词: 蛹虫草 虫草素 虫草多糖 抗肿瘤 生物利用度 |
| 英文关键词:Cordyceps militaris cordycepin Cordyceps polysaccharides antitumor bioavailability |
| 基金项目:国家重大战略需求和地方经济社会发展专项（31920250079）；甘肃省卫生健康行业科研计划（GSWSKY2023-34）；甘肃省青年基金（23JRRA1673）；兰州市青年科技人才创新项目（2024-QN-39）；甘肃省重点研发计划（2022-0203-SFC-0221） |
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| 中文摘要: |
| 摘 要：蛹虫草是一种药食兼用的真菌，其活性成分主要包括虫草素、虫草多糖、麦角甾醇及硒元素等。近年来，蛹虫草活性成分因其抗氧化、抗炎、抗肿瘤和免疫调节等多种作用而备受关注。目前大量研究聚焦于其生物活性成分、药理作用及其产业化应用方面。全文系统综述了蛹虫草活性成分在抗肿瘤分子机制中的研究进展，比较了虫草素和虫草多糖在细胞周期阻滞、细胞凋亡、自噬、调节免疫及耐药逆转等方面的作用差异，并总结了提高虫草素生物利用度的最新策略。以期为天然产物的深入研究提供理论基础，也为其在恶性肿瘤治疗中的开发应用提供新的思路。 |
| 英文摘要: |
| Abstract： Cordyceps militaris， a valued medicinal and edible fungus， contains a range of bioactive components， notably cordycepin， polysaccharides， ergosterol， and selenium. These constituents have attracted considerable research interest due to their multifaceted pharmacological properties， such as antioxidant， anti-inflammatory， antitumor， and immunomodulatory activities. While substantial studies have focused on their bioactivity and potential applications， a comprehensive review of their antitumor molecular mechanisms is lacking. This paper systematically summarizes recent advances in understanding how Cordyceps militaris bioactive components exert antitumor effects. It specifically compares the roles of cordycepin and Cordyceps polysaccharides in inducing cell cycle arrest， apoptosis， and autophagy， modu-lating immune responses， and reversing drug resistance. Furthermore， current strategies to improve the bioavailability of cordycepin are discussed. This review aims to provide directions for further research on natural antitumor agents and to offer novel perspectives for their development in cancer therapeutics. |
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