罗赛美,陈 杨,唐 娴,等.2016—2020年云南省肿瘤登记地区女性肺癌疾病负担分析及2021—2025年变化趋势预测[J].肿瘤学杂志,2026,32(6):495-502.
2016—2020年云南省肿瘤登记地区女性肺癌疾病负担分析及2021—2025年变化趋势预测
Disease Burden of Lung Cancer Among Female in Yunnan Cancer Registration Areas from 2016 to 2020 and Prediction from 2021 to 2025
投稿时间:2025-07-12  
DOI:10.11735/j.issn.1671-170X.2026.06.B007
中文关键词:  肺肿瘤  女性  疾病负担  趋势  预测  云南
英文关键词:lung neoplasms  female  disease burden  trends  prediction  Yunnan
基金项目:保山中医药高等专科学校百名中青年学术技术带头人培养项目(2025zd003)
作者单位
罗赛美 保山中医药高等专科学校 
陈 杨 云南省疾病预防控制中心 
唐 娴 云南省疾病预防控制中心 
伍福仙 云南省疾病预防控制中心 
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中文摘要:
      摘 要:[目的] 分析2016—2020年云南省肿瘤登记地区女性肺癌疾病负担变化趋势,预测2021—2025年的变化趋势,为肺癌流行病学研究及制定防治策略提供依据。[方法] 选取云南省16个有连续5年高质量肿瘤登记数据监测点的肺癌数据,按城乡、年龄别分组计算2016—2020年发病/死亡率、世界人口标化率(世标率)和中国人口标化率(中标率)、早死所致的健康生命损失年(years of life lost,YLL)及平均减寿年数(average years of life lost,AYLL)等指标;用Joinpoint Regression Program 4.8.1.0软件计算年度变化百分比(annual percentage change,APC)及95%置信区间(confidence interval,CI),分析变化趋势;用灰色系统模型预测未来5年肺癌疾病负担变化趋势。[结果] 2016—2020年,云南省女性肺癌粗发病率为28.27/10万(世标率16.46/10万,中标率16.68/10万),城市地区为28.78/10万(世标率16.41/10万,中标率16.52/10万),农村地区为27.57/10万(世标率16.54/10万,中标率16.71/10万);粗死亡率为18.93/10万(世标率10.37/10万,中标率10.54/10万),城市地区为19.34/10万(世标率10.40/10万,中标率10.62/10万),农村地区为18.27/10万(世标率10.31/10万,中标率10.56/10万);发病率和死亡率在0~44岁年龄段均处于较低水平,45岁后迅速升高,均在80~84岁年龄组达到高峰。2016—2020年,云南省女性肺癌的发病率呈逐年上升趋势(APC=5.2%,95%CI:2.8%~7.7%),城市地区和农村地区的上升幅度接近(城市APC=5.2%,95%CI:1.5%~9.1%;农村APC=5.2%,95%CI:0.9~9.7%);同时期,死亡率的年度变化趋势平稳。YLL、YLL率、AYLL均呈逐年下降趋势(APC=-2.3%,95%CI:-4.3%~-0.2%;APC=-3.2%,95%CI:-5.9%~-0.4%;APC=-2.5%,95%CI:-3.8%~-1.2%)。灰色模型预测显示,2021—2025年云南省女性肺癌的发病率将持续上升,从2020年的31.45/10万上升到2025年的42.24/10万(城市地区从32.38/10万上升到45.73/10万,农村地区从30.80/10万上升到37.07/10万);45~65岁年龄段死亡率将持续下降,由2020年的16.46/10万下降到2025年的10.57/10万(城市地区由16.97/10万下降到12.55/10万);65岁及以上年龄组YLL由2020年的4 566.98年上升到2025年的5 732.90年。[结论] 云南省肿瘤登记地区女性肺癌发病率和死亡率均处于较低水平,年龄越大发病率和死亡率越高,45岁后增长迅速;2016—2020年,云南省女性肺癌发病率呈逐年上升趋势,将在2021—2025年间持续上升,同时期死亡率的变化趋势平稳,YLL、YLL率、AYLL均呈下降趋势。防治中要重视肺癌三级预防,同时也应关注女性的健康教育及肺癌危险因素专项研究,继续开展45岁及以上人群肺癌早诊早治工作,降低肺癌的疾病负担。
英文摘要:
      Abstract: [Objective] To analyze the disease burden of lung cancer among female in Yunnan cancer registration areas from 2016 to 2020 and to predict the trends form 2021 to 2025. [Methods] Data were extracted from 16 population-based cancer registries in Yunnan Province with five consecutive years of high-quality data. The crude and age-standardized incidence and mortality rates by Chinese and world standard populations (ASIRC/ASMRC; ASIRW/ASMRW), years of life lost (YLL), and average years of life lost (AYLL) were calculated , stratified by urban/rural residence and age group. Trends were analyzed using the Joinpoint Regression Program (version 4.8.1.0), and future trends were predicted using a grey system model. [Results] From 2016 to 2020, the crude incidence rate of lung cancer among female was 28.27/105 (ASIRW: 16.46/105; ASIRC: 16.68/105), with rates of 28.78/105 in urban and 27.57/105 in rural areas. The crude mortality rate was 18.93/105 (ASMRW: 10.37/105; ASMRC: 10.54/105), with rates of 19.34/105 in urban and 18.27/105 in rural areas. Incidence and mortality were low before age 45, increased rapidly thereafter, and peaked in the 80~84 years old age group. The incidence showed a significant increasing trend from 2016 to 2020 [annual percentage change (APC)=5.2%, 95%CI: 2.8%~7.7%], with similar increases in both urban and rural areas. Mortality remained stable during this period. YLL, YLL rate, and AYLL all showed significant decreasing trends(APC=-2.3%, -3.2%, and -2.5%, respectively). The grey model predicted that the incidence would continue to rise from 31.45/105 in 2020 to 42.24/105 in 2025. Mortality in the age group of 45~65 years old was predicted to decline from 16.46/105 to 10.57/105. YLL in the age group of ≥65 years old was predicted to increase from 4 566.98 to 5 732.90 years. [Conclusion] The incidence and mortality of lung cancer among female in Yunnan are relatively low but increase rapidly after age 45. From 2016 to 2020, incidence rose significantly and is predicted to continue increasing through 2025, while mortality remained stable and YLL-related indicators declined.
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