| 中文关键词: 肺肿瘤 神经免疫 肿瘤微环境 肿瘤免疫逃避 神经周围侵犯 |
| 英文关键词:lung neoplasms neuroimmunity tumor microenvironment tumor immune escape perineural invasion |
| 基金项目:山东省自然科学基金青年基金（ZR2023QH545） |
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| 摘要点击次数: 5 |
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| 中文摘要: |
| 摘 要：肺癌是全球最常见、致死率最高的恶性肿瘤。肿瘤免疫逃逸在肿瘤发生及进展过程中发挥重要作用。然而，最近的研究揭示了肿瘤微环境中神经系统与免疫系统之间复杂且活跃的相互作用，这种双向交互作用显著影响着肿瘤的生长、转移潜能以及对免疫治疗的反应。在此背景下，“神经-免疫-肿瘤学轴”概念的提出，为理解肺癌进展机制及开发新型治疗策略提供了全新的视角。全文旨在系统梳理肺癌中神经系统与免疫系统相互作用的研究进展，以期未来通过靶向该信号轴治疗肺癌提供理论依据与潜在策略。 |
| 英文摘要: |
| Abstract： Lung cancer remains one of the most prevalent and lethal malignancies worldwide. Tumor immune evasion has long been recognized as a critical driver of tumor initiation and progression. However， emerging evidence in recent years has revealed complex and dynamic interactions between the nervous and immune systems within the tumor microenvironment. This bidirectional crosstalk critically regulates tumor growth， metastatic potential， and responsiveness to immunotherapy. In this context， the concept of the “neuro-immune-tumor axis” provides a novel perspective for elucidating the mechanisms underlying lung cancer progression and for developing innovative therapeutic strategies. This review aims to summarize recent advances in understanding the interplay between the nervous and immune systems in lung cancer， offering a reference for future lung cancer treatment by targeting this signaling axis. |
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