| 肖师松,贾国华,王晓黎,等.海南省适龄女生人乳头瘤病毒疫苗接种安全性评价及其母亲知信行调查[J].肿瘤学杂志,2026,32(5):385-390. |
| 海南省适龄女生人乳头瘤病毒疫苗接种安全性评价及其母亲知信行调查 |
| Safety of Human Papillomavirus Vaccination in Eligible Adolescent Females and A Survey on Their Mothers’ Knowledge， Attitudes， and Practices in Hainan Province |
| 投稿时间：2025-06-01 |
| DOI：10.11735/j.issn.1671-170X.2026.05.B005 |
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| 中文关键词: 人乳头瘤病毒 疫苗 疫苗接种 不良反应 知信行 |
| 英文关键词:human papillomavirus vaccine vaccination adverse reactions knowledge, attitude, and practice |
| 基金项目:海南省优秀人才团队资助（琼人才办通【2021】21号）；海南省临床医学中心建设项目资助（琼卫医函【2021】75号）；海南省卫生健康科技创新联合项目（WSJK2024MS140） |
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| 中文摘要: |
| 摘 要：［目的］ 评估海南省适龄女生（13.0~14.5岁）人乳头瘤病毒（human papillomavirus，HPV）疫苗接种的安全性，并分析适龄女生母亲接种HPV疫苗的影响因素。［方法］ 调查2023年11月至2024年1月海南省18个市县适龄女生HPV疫苗接种后不良反应情况，并调查适龄女生母亲的HPV和HPV疫苗相关知识的知晓程度以及HPV疫苗接种情况。采用SPSS 26.0统计软件进行数据分析，采用Logistic回归分析适龄女生母亲HPV疫苗接种的影响因素。［结果］ 在6 163人HPV疫苗接种适龄女生中，1 427人发生局部不良反应，局部不良反应发生率为23.15%（1 427/6 163）。1 485人出现全身不良反应，全身不良反应发生率为24.10%（1 485/6 163）。影响日常活动的不良反应发生率均小于5%。3 883人无任何不良反应，占总人数的63.00%。适龄女生母亲HPV疫苗接种人数达1 666人，HPV疫苗接种率为27.03%。多因素分析显示，年龄（OR=1.473，95%CI：1.326~1.637）、文化程度（OR=0.887，95%CI：0.831~0.948）、HPV和HPV疫苗知晓程度（OR=0.884，95%CI：0.870~0.898）及家庭月收入（OR=0.880，95%CI：0.813~0.952）是适龄女生母亲接种HPV疫苗的影响因素（P＜0.05）。［结论］ 海南省适龄女生HPV疫苗接种的不良反应发生率低，其安全性高。文化程度、HPV和HPV疫苗知晓程度、年龄及家庭月收入是影响适龄女生母亲HPV疫苗接种的影响因素。 |
| 英文摘要: |
| Abstract： ［Objective］ To evaluate the safety of human papillomavirus(HPV) vaccination among eligible adolescent female students(aged 13.0~14.5 years old) in Hainan Province， and to analyze the factors influencing HPV vaccination among their mothers. ［Methods］ From November 2023 to January 2024， a survey on adverse reactions to HPV vaccination was conducted among eligible female students participating in the HPV vaccination program across 18 cities and counties of Hainan Province. Simultaneously， a knowledge， attitude， and practice (KAP) questionnaire regarding HPV and HPV vaccine， as well as HPV vaccination status， was administered to the mothers of these same vaccinated students. Data were analyzed using SPSS 26.0， and Logistic regression was used to identify factors associated with mothers’ HPV vaccination. ［Results］ A total of 6 163 eligible female students who received HPV vaccination were included. Among them， 1 427 (23.15%) experienced local adverse reactions， and 1 485(24.10%) experienced systemic adverse reactions. The incidence of adverse reactions affecting daily activities was less than 5%. No adverse reaction was reported in 3 883 students (63.00%). Among the mothers of these vaccinated students， 1 666 had received HPV vaccination， yielding a vaccination rate of 27.03%. Multivariate Logistic regression identified age (OR=1.473， 95%CI： 1.326~1.637)， educationa (OR=0.887， 95%CI： 0.831~0.948)， awareness of HPV and HPV vaccination (OR=0.884， 95%CI： 0.870~0.898)， and monthly household income (OR=0.880， 95%CI： 0.813~0.528) as factors independently associated with mothers’ HPV vaccination (all P<0.05). ［Conclusion］ The incidence of adverse reactions to HPV vaccination among eligible adolescent female students in Hainan Province is low， indicating favorable safety. Maternal educational level， awareness of HPV and HPV vaccine， age， and monthly household income are important factors influencing HPV vaccination uptake. |
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