| 高吉秘,魏 芳.脂质代谢重编程对卵巢癌生长、转移、耐药的驱动机制与未来挑战[J].肿瘤学杂志,2026,32(5):353-361. |
| 脂质代谢重编程对卵巢癌生长、转移、耐药的驱动机制与未来挑战 |
| Lipid Metabolic Reprogramming in Ovarian Cancer： Mechanisms Driving Progression，Therapy Resistance， and Future Directions |
| 投稿时间：2025-07-23 |
| DOI：10.11735/j.issn.1671-170X.2026.05.B001 |
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| 中文关键词: 卵巢肿瘤 脂质代谢 重编程 肿瘤微环境 化疗耐药 |
| 英文关键词:ovarian neoplasms lipid metabolism reprogramming tumor microenvironment chemotherapy resistance |
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| 摘要点击次数: 9 |
| 全文下载次数: 1 |
| 中文摘要: |
| 摘 要：近年研究发现，脂质代谢重编程通过提供合成原料、能量供应及激活增殖信号通路，驱动卵巢癌恶性进展；同时脂质代谢重编程参与肿瘤微环境互相作用，尤其是与大网膜脂肪细胞的代谢串扰，介导化疗耐药。全文系统综述脂质代谢异常在卵巢癌细胞增殖、凋亡、迁移、侵袭及耐药中的双重作用机制，提出靶向脂质合成关键酶及联合铁死亡诱导剂的治疗新策略，并强调基于脂质代谢标志物的早期诊断价值。未来需深入解析脂质代谢网络交互机制，推动多靶点联合疗法及中医药协同干预的临床转化。 |
| 英文摘要: |
| Abstract： Lipid metabolic reprogramming has emerged as a critical driver of ovarian cancer pathogenesis. It fuels tumor progression by supplying essential biosynthetic precursors and energy， while simultaneously activating key proliferative signaling pathways. Furthermore， this reprogramming facilitates dynamic interactions within the tumor microenvironment， notably through metabolic crosstalk with omental adipocytes， thereby contributing to the development of chemotherapy resistance. This paper systematically synthesizes the dualistic roles of aberrant lipid metabolism in modulating ovarian cancer cell behaviors—including proliferation， apoptosis， migration， invasion， and drug resistance. We also propose novel therapeutic strategies centered on inhibiting key lipid synthesis enzymes， potentially in combination with ferroptosis inducers. The value of metabolism-derived biomarkers for early detection is also underscored. Moving forward， a deeper mechanistic understanding of the complex networks governing lipid metabolism is essential to advance the clinical translation of multi-target combination therapies and integrated approaches that may include traditional Chinese medicine. |
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