| 马 飞,武小侠,张定虎,等.纳米放射增敏剂在放疗诱导免疫原性细胞死亡中的作用机制及研究进展[J].肿瘤学杂志,2026,32(4):343-352. |
| 纳米放射增敏剂在放疗诱导免疫原性细胞死亡中的作用机制及研究进展 |
| Mechanisms and Research Progress of Nanoradiosensitizers in Radiotherapy-Induced Immunogenic Cell Death |
| 投稿时间：2025-08-25 |
| DOI：10.11735/j.issn.1671-170X.2026.04.B010 |
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| 中文关键词: 纳米放射增敏剂 免疫原性细胞死亡 放射疗法 免疫治疗 |
| 英文关键词:nanoradiosensitizers immunogenic cell death radiotherapy immunotherapy |
| 基金项目: |
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| 摘要点击次数: 9 |
| 全文下载次数: 6 |
| 中文摘要: |
| 摘 要：纳米放射增敏剂作为提升肿瘤放射治疗效能的前沿策略，能够增强电离辐射对肿瘤细胞的损伤作用，并弥补传统放疗在诱导免疫原性细胞死亡（immunogenic cell death，ICD）方面的不足。近年来，相关研究表明纳米放射增敏剂不仅可显著提高肿瘤放射敏感性，还可通过促进ICD发生，推动放疗与机体抗肿瘤免疫应答的协同增强，为改善免疫治疗应答率提供新的可能性。全文综述了纳米放射增敏剂诱导ICD的机制，重点讨论了无机、无机-有机结合以及有机放射增敏剂的研究进展，探讨了放射增敏剂与化疗、靶向治疗及免疫治疗等其他治疗手段的联合应用进展，为提高肿瘤治疗效果提供新的方向。并展望纳米放射增敏剂与介入治疗相结合的潜在应用，旨在通过多模态治疗策略的应用，进一步提升肿瘤治疗的疗效，推动肿瘤综合治疗的新进展。 |
| 英文摘要: |
| Abstract： Nanoradiosensitizers， as a cutting edge strategy to enhance the efficacy of tumor radiotherapy， not only intensify the cytotoxic effects of ionizing radiation on tumor cells but also compensate for the limited ability of conventional radiotherapy to induce immunogenic cell death(ICD). Recent studies have demonstrated that nanoradiosensitizers can significantly increase tumor radiosensitivity and promote ICD， thereby synergistically amplifying the antitumor immune response elicited by radiotherapy and offering new possibilities for improving the response rate to immunotherapy. This review summarizes the mechanisms by which nanoradiosensitizers induce ICD and highlights recent progress in inorganic， inorganic organic hybrid， and organic radiosensitizers. The combinatorial applications of radiosensitizers with chemotherapy， targeted therapy， immunotherapy， and other treatment modalities are also discussed， providing new directions for enhancing therapeutic outcomes. Furthermore， the potential integration of nanoradiosensitizers with interventional therapy is prospected， aiming to further improve antitumor efficacy through multimodal treatment strategies and advance the development of comprehensive cancer therapy. |
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