| 方 黎,李 伟.97例食管癌组织中α-平滑肌肌动蛋白、CD34和Ki-67表达及与临床病理特征关系[J].肿瘤学杂志,2026,32(3):225-231. |
| 97例食管癌组织中α-平滑肌肌动蛋白、CD34和Ki-67表达及与临床病理特征关系 |
| Expression of α-Smooth Muscle Actin， CD34， and Ki-67 in Esophageal Cancer Tissues and Their Associations with Clinicopathological Characte-ristics |
| 投稿时间：2025-07-18 |
| DOI：10.11735/j.issn.1671-170X.2026.03.B007 |
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| 中文关键词: 食管肿瘤 平滑肌肌动蛋白 CD34 Ki?鄄67 临床病理特征 脉管侵犯 |
| 英文关键词:esophageal neoplasms smooth muscle actin CD34 Ki-67 clinical pathological characteristic vascular invasion |
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| 中文摘要: |
| 摘 要：［目的］ 探讨食管癌组织中α-平滑肌肌动蛋白（α-smooth muscle actin，α-SMA）、CD34和Ki-67的表达情况及其与临床病理特征的关系。［方法］ 选取2021年1月至2024年12月许昌市中心医院收治的97例食管癌患者为研究对象，收集其癌组织及癌旁组织标本。检测组织中α-SMA、CD34、Ki-67的表达水平，分析其与临床病理特征的关系。再根据患者有无脉管侵犯分为脉管侵犯组39例（40.21%）与无脉管侵犯组58例（59.79%），采用Logistic回归分析影响食管癌患者脉管侵犯的因素，受试者工作特征（receiver operating characteristic，ROC）曲线评估α-SMA、CD34、Ki-67表达对食管癌患者脉管侵犯的诊断价值。［结果］ 癌组织中α-SMA、CD34、Ki-67阳性率均高于癌旁组织（P均<0.001）。α-SMA、CD34、Ki-67的高表达与TNM分期、分化程度、淋巴结转移、脉管侵犯等临床病理特征相关（P均<0.05）。脉管侵犯组TNM分期Ⅲ~Ⅳ期、低分化、淋巴结转移、α-SMA高表达、CD34高表达、Ki-67高表达的比例均高于无脉管侵犯组（P<0.05）。Logistic回归分析显示，TNM分期、分化程度、淋巴结转移、α-SMA高表达、CD34高表达、Ki-67高表达是食管癌患者脉管侵犯的影响因素（P<0.05）。α-SMA、CD34、Ki-67及三者联合检测对食管癌患者脉管侵犯诊断的ROC曲线下面积分别为0.721、0.669、0.703、0.864。［结论］ α-SMA、CD34和Ki-67在食管癌组织中高表达，且与TNM分期、分化程度、淋巴结转移、脉管侵犯等临床病理特征密切相关，三者可作为评估食管癌恶性程度及预后的潜在生物标志物，为临床诊疗提供依据。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the expression of α-smooth muscle actin (α-SMA)， CD34 and Ki-67 in esophageal cancer tissues and their associations with clinicopathological characteristics. ［Methods］ A total of 97 patients with esophageal cancer who underwent treatment at Xuchang Central Hospital between January 2021 and December 2024 were enrolled. Specimens of cancer tissues and adjacent tissues were collected. The expression levels of α-SMA， CD34， and Ki-67 were detected， and their relationships with clinicopathological characteristics were analyzed. Patients were stratified into a vascular invasion group (39 cases， 40.21%) and a non-vascular invasion group (58 cases， 59.79%) based on pathological findings. Clinical data were compared between the two groups. Logistic regression analysis was employed to identify factors influencing vascular invasion， and the diagnostic value of α-SMA， CD34， and Ki-67 expression for vascular invasion was evaluated using receiver operating characteristic (ROC) curve analysis. ［Results］ The positive expression rates of α-SMA， CD34， and Ki-67 were significantly higher in cancer tissues compared to adjacent tissues (all P<0.001). High expression of α-SMA， CD34， and Ki-67 was correlated with advanced TNM stage， poorly differentiation， lymph node metastasis， and vascular invasion (all P<0.05). The vascular invasion group exhibited significantly higher proportions of stage Ⅲ~Ⅳ disease， poorly differentiation， lymph node metastasis， and high expression of α-SMA， CD34， and Ki-67 compared to the non-vascular invasion group (all P<0.05). Logistic regression analysis identified TNM stage， differentiation grade， lymph node metastasis， and high expression of α-SMA， CD34， and Ki-67 as independent influencing factors for vascular invasion (all P<0.05). The areas under the ROC curve (AUC) for diagnosing vascular invasion using α-SMA， CD34， and Ki-67 alone were 0.721， 0.669， and 0.703， respectively， while the combined detection of all three markers yielded an AUC of 0.864. ［Conclusion］ α-SMA， CD34， and Ki-67 are highly expressed in esophageal cancer tissues and are closely associated with adverse clinicopathological features， including advanced TNM stage， poorly differentiation， lymph node metastasis， and vascular invasion. These three markers may serve as potential biomarkers for assessing tumor aggressiveness and prognosis in esophageal cancer， providing valuable insights for clinical diagnosis and treatment. |
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