| 张诗茹,林燕明,杨志雄.非小细胞肺癌脑膜转移诊治的研究进展[J].肿瘤学杂志,2026,32(3):208-214. |
| 非小细胞肺癌脑膜转移诊治的研究进展 |
| Advances in the Diagnosis and Treatment of Leptomeningeal Metastasis of Non-Small Cell Lung Cancer |
| 投稿时间：2025-04-27 |
| DOI：10.11735/j.issn.1671-170X.2026.03.B005 |
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| 中文关键词: 非小细胞肺癌 脑膜转移 诊断 鞘内化疗 靶向治疗 免疫治疗 |
| 英文关键词:non-small cell lung cancer leptomeningeal metastases diagnosis intrathecal chemotherapy targeted therapy immunotherapy |
| 基金项目:国家自然科学基金（81871883） |
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| 摘要点击次数: 24 |
| 全文下载次数: 11 |
| 中文摘要: |
| 摘 要：非小细胞肺癌（non-small cell lung cancer，NSCLC）脑膜转移临床表现缺乏特异性，传统影像学与脑脊液细胞学检查存在一定局限性。近年来，脑脊液循环肿瘤DNA检测技术的进展显著提升了脑膜转移的早期诊断与分子分型能力。治疗方面，目前尚未形成统一的标准化方案。针对驱动基因阳性患者，优选靶向药物及鞘内化疗，耐药后可考虑高剂量方案；对于驱动基因阴性患者，免疫治疗显示出一定的应用前景。全文综述了NSCLC脑膜转移在诊断与治疗方面的最新研究进展，为临床实践提供参考。 |
| 英文摘要: |
| Abstract： Leptomeningeal metastasis (LM) in non-small cell lung cancer (NSCLC) is characterized by nonspecific clinical manifestations and limitations of traditional imaging and cerebrospinal fluid (CSF) cytology. In recent years， advances in CSF circulating tumor DNA(ctDNA) analysis have significantly enhanced early detection and molecular subtyping of LM. Currently， there is no unified standard treatment protocol. For driver gene-positive patients， targeted therapy and intrathecal chemotherapy are preferred， with high-dose regimens considered upon resistance. For driver gene-negative patients， immunotherapy demonstrates considerable potential. This review summarizes recent progress in the diagnosis and management of NSCLC-related LM， offering insights for clinical practice. |
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