| 宋倩男,雷 雪,刘松江.肠-肺轴调控肺癌发生及进展、免疫机制及其临床干预策略的研究进展[J].肿瘤学杂志,2026,32(2):164-170. |
| 肠-肺轴调控肺癌发生及进展、免疫机制及其临床干预策略的研究进展 |
| Research Progress on Gut-Lung Axis Regulation of Occurrence/Progression and Immune Mechanisms of Lung Cancer and Its Clinical Intervention Strategies |
| 投稿时间：2025-08-05 |
| DOI：10.11735/j.issn.1671-170X.2026.02.B011 |
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| 中文关键词: 肠-肺轴 肠道菌群 肺肿瘤 免疫治疗 代谢调控 |
| 英文关键词:gut-lung axis gut microbiota lung neoplasms immunotherapy metabolic regulation |
| 基金项目:黑龙江省中医药科研项目（GY2022-05）；黑龙江中医药大学附属第一医院国家自然科学基金培育支持计划面上项目（PYMS202501004） |
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| 中文摘要: |
| 摘 要：“肠-肺轴”作为肠道菌群与远端肺部疾病之间的关键桥梁，已成为肿瘤免疫研究的前沿领域。全文系统综述了肠道菌群通过免疫调节、代谢产物介导及系统性炎症途径调控肺癌发生、进展及免疫治疗应答的分子机制。重点分析了肠道微生物组作为预测免疫检查点抑制剂（immune checkpoint inhibitor，ICI）疗效的生物标志物价值，并深入探讨了基于微生物组的干预策略，如粪菌移植（fecal microbiota transplantation，FMT）、益生菌、益生元及饮食调整的临床前与临床研究。并评估了Ⅲ期临床研究对肠道菌群作用的支持证据，并对当前挑战和未来转化方向进行了总结与展望，旨在为肺癌的精准免疫治疗提供新思路。 |
| 英文摘要: |
| Abstract： The gut-lung axis， which mediates cross-talk between the gut microbiota and lung pathophysio-logy， represents an emerging frontier in oncology. This review comprehensively delineates the mechanisms through which the gut microbiota influences lung carcinogenesis， progression， and response to immunotherapy， with a focus on immune regulation， microbial metabolite signaling， and systemic inflammation. This review critically assess the potential of the gut microbiome to serve as a predictive biomarker for immune checkpoint inhibitor (ICI) efficacy and evaluate microbiome-targeted interventions—including fecal microbiota transplantation (FMT)， probiotics， prebiotics， and dietary modulation—drawing on evidence from both preclinical and clinical studies. Furthermore， this review synthesize findings from phase Ⅲ trials that underscore the role of gut microbiota， discuss prevailing challenges， and propose future directions for translational research， with the aim of informing novel strategies for precision immunotherapy in lung cancer. |
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