| 中文关键词: 重离子 放射疗法 布拉格峰 相对生物学效应 治疗计划系统 质量控制 |
| 英文关键词:heavy ion radiotherapy Bragg peak relative biological effectiveness treatment planning system quality control |
| 基金项目:浙江省医药卫生科技计划项目（2025KY038） |
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| 中文摘要: |
| 摘 要：重离子放射治疗作为现代精准放射治疗的重要代表，近年来在肿瘤治疗领域取得了突破性进展。与传统光子放疗相比，重离子束具有独特的布拉格峰剂量分布特性，能够在肿瘤靶区形成高度集中的剂量沉积，同时显著减少周围正常组织的辐射损伤。更为重要的是，重离子束具有更高的相对生物学效应，这种特性使重离子对传统放射抗拒的肿瘤类型（如恶性黑色素瘤、骨肉瘤、脊索瘤等）具有更好的杀伤效果。全文围绕重离子束的物理特性、剂量学特性、治疗计划系统、影像引导技术、呼吸运动管理和质量控制等方面，系统分析了重离子放射治疗的关键物理技术挑战和解决方案，并展望了该领域的未来发展方向。 |
| 英文摘要: |
| Abstract： Heavy ion radiotherapy， as a leading modality in modern precision radiotherapy， has made significant progress in cancer treatment in recent years. Compared with conventional photon radiotherapy， heavy ion beams exhibit a unique Bragg peak dose distribution， enabling highly concentrated dose deposition within the tumor target while substantially reducing radiation exposure to surrounding healthy tissues. More importantly， heavy ion beams possess a higher relative biological effectiveness. This characteristic makes them particularly effective against tumor types traditionally resistant to radiation， such as malignant melanoma， osteosarcoma， and chordoma. This paper provides a systematic analysis of the key physical and technical challenges and corresponding solutions in heavy ion radiotherapy， covering aspects including the physical and dosimetric properties of heavy-ion beams， treatment planning systems， image-guided technologies， respiratory motion management， and quality assurance. Future directions in this field are also discussed. |
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