| 杜嘉慧,王 宇,王立哲,等.内质网应激反应与自噬在肿瘤耐药中的相互作用[J].肿瘤学杂志,2025,31(11):988-995. |
| 内质网应激反应与自噬在肿瘤耐药中的相互作用 |
| Interelationship Between Endoplasmic Reticulum Stress and Autophagy in Tumor Resistance |
| 投稿时间：2024-11-19 |
| DOI：10.11735/j.issn.1671-170X.2025.11.B009 |
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| 中文关键词: 内质网应激 自噬 肿瘤 耐药性 |
| 英文关键词:endoplasmic reticulum stress autophagy tumor resistance |
| 基金项目:安徽医科大学校科研青年科学基金项目（2023xkj110） |
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| 摘要点击次数: 5 |
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| 中文摘要: |
| 摘 要：内质网是细胞内重要的细胞器，是脂质合成和新生跨膜蛋白折叠与分泌的关键部位，对细胞内稳态维持具有重要作用。当细胞受内、外界刺激因素影响使内环境稳态失衡，内质网信号传感器对内部紊乱做出应激反应——内质网应激，并向下游激活未折叠蛋白质反应作为细胞激活保护机制来恢复蛋白质质与量的平衡。持续或高强度的内质网应激可激活细胞自噬，通过降解受损的细胞器或多余细胞质，减轻氧化损伤，维持细胞的正常生理活动。内质网稳态和自噬对于多种肿瘤进展、转移和化疗耐药性至关重要。内质网应激发出多个信号以诱导自噬，从而发挥细胞保护作用。因此，靶向内质网应激及其介导的自噬或许是开发新型肿瘤疗法的可行方法。全文对内质网应激和自噬之间的相互关系作一综述，并探究两者在肿瘤耐药中的作用机制，以开发潜在的临床价值。 |
| 英文摘要: |
| Abstract： The endoplasmic reticulum (ER) is an essential intracellular organelle that plays a pivotal role in various cellular processes， including lipid synthesis， the folding and secretion of transmembrane proteins， and the maintenance of intracellular homeostasis. When cells are affected by internal or external stimuli that disrupt the homeostasis of the internal environment， the endoplasmic reticulum signalling sensors respond to the internal disorder by initiating endoplasmic reticulum stress (ERS) and activating the unfolded protein response (UPR) downstream as a cytoprotective mechanism to restore the qualitative and quantitative balance of intracellular proteins. Sustained or high-intensity endoplasmic reticulum stress activates autophagy， which mitigates oxidative damage and maintains normal cellular physiological activities by degrading damaged organelles or excess cytoplasm. ER homeostasis and autophagy are essential for tumor progression， metastasis and chemoresistance. Furthermore， ERS triggers multiple signaling pathways that induce autophagy so as to cytoprotective effects. Therefore， targeting ERS and the autophagy it mediates may be a viable approach for developing new cancer therapies. This paper summarizes the interrelationship between endoplasmic reticulum stress and autophagy based on the latest research advances， and explores their mechanisms of action in tumor drug resistance， aiming to identify potential clinical applications. |
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