| 朱玉芬,李伟东,剧亚茹,等.HIF-1α及IGSF9在子宫内膜癌中的表达及其与预后相关性[J].肿瘤学杂志,2025,31(11):945-951. |
| HIF-1α及IGSF9在子宫内膜癌中的表达及其与预后相关性 |
| Expression of HIF-1α and IGSF9 in Endometrial Cancer and Their Significance of Prognosis |
| 投稿时间：2025-06-12 |
| DOI：10.11735/j.issn.1671-170X.2025.11.B004 |
|
 |
| 中文关键词: 子宫内膜肿瘤 免疫球蛋白超家族成员9 缺氧诱导因子-1α 预后 |
| 英文关键词:endometrial neoplasms immunoglobulin superfamily member 9 hypoxia-inducible factor-1α prognosis |
| 基金项目:石家庄市科学技术研究与发展计划（231200293） |
|
| 摘要点击次数: 7 |
| 全文下载次数: 1 |
| 中文摘要: |
| 摘 要：［目的］ 探讨免疫球蛋白超家族成员9（immunoglobulin superfamily member 9，IGSF9）及缺氧诱导因子-1α（hypoxia-inducible factor-1α，HIF-1α）在子宫内膜癌（endometrial cancer，EC）中的表达及其与预后的相关性。［方法］ 选取石家庄市第四医院EC患者82例，同期子宫内膜不典型增生（endometrial intraepithelial neoplasia，EIN）患者54例，癌旁正常子宫内膜组织52例。采用免疫组织化学染色及实时荧光定量聚合酶链式反应检测IGSF9、HIF-1α蛋白及IGSF9、HIF-1α mRNA表达，Kaplan-Meier法绘制生存曲线， Cox回归分析IGSF9、HIF-1α蛋白与EC患者临床病理特征及预后关系。［结果］ 在EC、EIN及正常子宫内膜中，IGSF9蛋白阳性表达率分别为56.10%、35.18%、23.08%，HIF-1α蛋白阳性表达率分别为68.29%、44.44%、34.61%，差异均具有统计学意义（IGSF9：χ2=15.392，P<0.001；HIF-1α：χ2=16.254，P<0.001）。EC组织中IGSF9、HIF-1α蛋白表达与淋巴结转移、FIGO分期、肌层浸润深度相关（P均<0.05）。IGSF9及HIF-1α mRNA在EC中表达水平均高于EIN及正常子宫内膜（P均<0.01）。多因素Cox回归分析表明IGSF9表达是EC患者预后差的独立影响因素（HR=3.279，95%CI：1.096~9.817）。IGSF9阳性EC患者5年总生存率低于阴性者（50.0% vs 88.9%，χ2=11.438，P=0.001）。HIF-1α阳性EC患者5年总生存率也低于阴性者，但差异无统计学意义（62.5% vs 76.9%，χ2=3.424，P=0.064）。［结论］ IGSF9及HIF-1α在EC中高表达，可能共同参与EC进展及转移。 |
| 英文摘要: |
| Abstract： ［Objective］ To investigate the expression of hypoxia-inducible factor-1α (HIF-1α) and immunoglobulin superfamily member 9 (IGSF9)， and their association with prognosis in endometrial carcinoma (EC). ［Methods］ A total of 82 EC， 54 endometrial intraepithelial neoplasia (EIN)， and 52 normal endometrial tissue were collected from The Fourth Hospital of Shijiazhuang. Immunohistochemistry and quantitative real-time polymerase chain reaction were used to detect the expression of HIF-1α and IGSF9 at the protein and mRNA levels， respectively. Survival curves were plotted using the Kaplan-Meier method， and Cox regression analysis was conducted to explore the relationship between IGSF9 and HIF-1α expression and the clinicopathological characteristics and prognosis of EC patients. ［Results］ The positive expression rates of IGSF9 protein in EC， EIN and normal endometrium were 56.10%， 35.18% and 23.08%， respectively， and the positive expression rates of HIF-1α protein were 68.29%， 44.44% and 34.61%， respectively. The differences were statistically significant (IGSF9： χ2=15.392， P<0.001； HIF-1α： χ2=16.254， P<0.001). The expression of IGSF9 and HIF-1α expression in EC tissues were related to lymph node metastasis， FIGO stage and infiltrative depth (all P<0.05). The expression levels of IGSF9 and HIF-1α mRNA in EC were both higher than those in EIN and normal endometrium (all P<0.01). Multivariate Cox regression analysis showed that the IGSF9 expression was an independent influencing factor for poorly prognosis in EC patients(HR=3.279， 95%CI： 1.096~9.817). The 5-year overall survival of IGSF9-positive EC patients was lower than that of the negative group (50.0% vs 88.9%， χ2=11.438， P=0.001). The 5-year overall survival of HIF-1α-positive EC patients was also lower than that of the negative group， but the difference was not statistically significant (62.5% vs 76.9%， χ2=3.424， P=0.064). ［Conclusion］ HIF-1α and IGSF9 are upregulated in EC， and may jointly contribute to disease progression and metastasis. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |