| 杜雪龙,杨晓军.肝癌干细胞与肿瘤相关巨噬细胞相互作用的调控机制及其在肝癌治疗中的研究进展[J].肿瘤学杂志,2025,31(10):896-908. |
| 肝癌干细胞与肿瘤相关巨噬细胞相互作用的调控机制及其在肝癌治疗中的研究进展 |
| Regulation Mechanism of Interaction Between Hepatocellular Carcinoma Stem Cells and Tumor-Associated Macrophages and Its Progress in Hepatocellular Carcinoma Treatment |
| 投稿时间：2024-11-27 |
| DOI：10.11735/j.issn.1671-170X.2025.10.B011 |
|
 |
| 中文关键词: 肝肿瘤 肝癌干细胞 分子标志物 肿瘤相关巨噬细胞 分子靶向治疗 |
| 英文关键词:liver neoplasms liver cancer stem cells molecular markers tumor-associated macrophages molecular targeted therapy |
| 基金项目:甘肃省人民医院院内科研基金项目（GSWSKY2020-45，22GSSYA-3）；国家卫健委胃肠肿瘤诊治重点实验室博士基金项目（NHCDP2022001） |
|
| 摘要点击次数: 58 |
| 全文下载次数: 12 |
| 中文摘要: |
| 摘 要： 肝细胞癌（hepatocellular carcinoma，HCC）是原发性肝癌中最常见的类型，占所有肝癌病例的90%以上。肿瘤干细胞（cancer stem cells，CSCs）是肿瘤中的一个小亚群，具有自我更新和无限增殖的特点。以往的研究表明，肿瘤干细胞具有高度的致瘤性、转移性和耐药性，并与肿瘤复发密切相关。肝癌干细胞（liver cancer stem cells，LCSCs）是导致HCC的原因，也是其复发的根本原因。巨噬细胞是引起慢性炎症反应的最重要细胞。浸润肿瘤组织或肿瘤微环境（tumor microenvironment，TME）的巨噬细胞称为肿瘤相关巨噬细胞（tumor-associated macrophages，TAMs）。TAMs是肿瘤炎症微环境中最重要的组成部分，影响着HCC细胞的各种恶性行为和肿瘤内的免疫逃逸状态。TAMs是炎症微环境与癌细胞间的“桥梁”。以TAMs为靶点抑制LCSCs的形成可能为HCC的治疗提供一种可能性。全文综述了LCSCs的特点、在HCC中的主要作用、TAMs的亚型和功能、LCSCs与TAMs的相互关系，并简要总结了TAMs相关抗HCC治疗靶点的最新科研成果，为HCC的治疗提供新思路。 |
| 英文摘要: |
| Abstract： Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer， accounting for more than 90% of all liver cancer cases. Cancer stem cells (CSCs) are a small subset of tumors with the cha-racteristics of self-renewal and infinite proliferation. Studies have shown that CSCs have a feature of high tumorigenicity， metastasis， and drug resistance， and are closely related to tumor recurrence. Liver cancer stem cells (LCSCs) are closely related to the carcinogenesis and recurrence of HCC. Macrophages are the most important cells causing chronic inflammatory reactions. Macrophages that infiltrate tumor tissues or tumor microenvironment (TME) are called tumor-associated macrophages (TAMs). TAMs are the most important component of the inflammatory microenvironment of tumors， involving in various malignant behaviors of HCC cells and the immune escape. TAMs serve as a “bridge” between the inflammatory microenvironment and CSCs. Targeting TAMs to inhibit the formation of LCSCs may provide a possibility for HCC treatment. This paper reviews the characteristics of LCSCs， their main role in HCC， the subtypes and functions of TAMs， and the interrelationship between LCSCs and TAMs， also summarizes the latest research results on TAMs-related anti-HCC therapeutic targets， which could provide a new idea for the treatment of HCC. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |