| 张 奎,文秀华,刘太阳,等.根治性膀胱切除术前最大限度经尿道膀胱肿瘤切除术对膀胱多发肿瘤患者预后的影响[J].肿瘤学杂志,2025,31(10):884-889. |
| 根治性膀胱切除术前最大限度经尿道膀胱肿瘤切除术对膀胱多发肿瘤患者预后的影响 |
| Analysis of the Effect of Maximal Transurethral Resection of Bladder Tumor Prior to Radical Cystectomy on the Prognosis of Patients with Multiple Bladder Tumors |
| 投稿时间：2025-01-22 |
| DOI：10.11735/j.issn.1671-170X.2025.10.B009 |
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| 中文关键词: 根治性膀胱切除术 经尿道膀胱肿瘤切除术 膀胱肿瘤 多发肿瘤 预后 |
| 英文关键词:radical cystectomy transurethral resection of bladder tumor bladder neoplasms multiple tumors prognosis |
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| 中文摘要: |
| 摘 要：［目的］ 探讨根治性膀胱切除术前最大限度经尿道膀胱肿瘤切除术（transurethral resection of bladder tumor，TURBT）对膀胱多发肿瘤患者预后的影响。［方法］ 回顾性分析2019年1月至2020年12月驻马店市中心医院收治的184例膀胱多发肿瘤患者的临床资料。依据TURBT切除范围，将患者分为最大限度切除组（112例）和诊断性电切组（72例），比较两组总生存率及无复发生存率。再依据术后4年是否存活，分为死亡组（48例）和存活组（136例），分析膀胱多发肿瘤患者预后的影响因素。［结果］ 最大限度切除组术后1年、3年和4年总生存率及无复发生存率均显著高于诊断性电切组（P<0.05）。病理分期、肿瘤数量、手术类型（最大限度切除 vs 诊断性电切）、淋巴结转移、术前新辅助化疗及ECOG评分是患者术后4年生存的影响因素（P<0.05）。Cox回归分析结果显示，肿瘤数量为2个及术前新辅助化疗是患者预后的独立保护因素（P<0.05），有淋巴结转移及ECOG评分高是患者预后的独立危险因素（P<0.05）。［结论］ 根治性膀胱切除术前最大限度TURBT对膀胱多发肿瘤患者的预后具有积极影响，能显著提高患者生存率。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the effect of maximal transurethral resection of bladder tumor (TURBT) prior to radical cystectomy on the prognosis of patients with multiple bladder tumors. ［Methods］ The clinical data of 184 patients with multiple bladder tumors admitted to Zhumadian Central Hospital from January 2019 to December 2020 were trospectively analyzed. Based on the extent of TURBT resection， the patients were divided into a maximal resection group (n=112) and a diagnostic electrocautery group (n=72). The overall survival and recurrence-free survival were compared between the two groups. Additionally， the patients were divided into a death group (n=48) and a survival group (n=136) based on their survival status at 4 years after surgery. The influencing factors of prognosis in patients with multiple bladder tumors were analyzed. ［Results］ The overall survival and recurrence-free survival at 1， 3， and 4 years after surgery of the maximum resection group were significantly higher than those of the diagnostic electrocautery group (P<0.05). Pathological stage， mumber of tumors， surgical type(maximal resection vs diagnostic electrocautery)， lymph node metastasis， preoperative neoadjuvant chemotherapy， and ECOG score were influencing factors for patients’ 4-year survival after surgery (P<0.05). Cox regression analysis results showed that a tumor number of 2 and preoperative neoadjuvant chemotherapy were independent protective factors for patient prognosis (P<0.05)， while lymph node metastasis and high ECOG score were independent risk factors for patient prognosis (P<0.05). ［Conclusion］ Maximal TURBT prior to radical cystectomy has a significant positive impact on the prognosis of patients with multiple bladder tumors and can significantly improve their survival. |
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