| 高莎莎,乔怡宁,秦明祎,等.中性粒细胞/白蛋白比值在胃癌术后患者中的临床价值[J].肿瘤学杂志,2025,31(10):859-864. |
| 中性粒细胞/白蛋白比值在胃癌术后患者中的临床价值 |
| Clinical Value of Neutrophil to Albumin Ratio in Postoperative Patients with Gastric Cancer |
| 投稿时间：2025-03-25 |
| DOI：10.11735/j.issn.1671-170X.2025.10.B005 |
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| 中文关键词: 胃肿瘤 中性粒细胞/白蛋白比值 预后 影响因素 总生存率 |
| 英文关键词:gastric neoplasms neutrophil to albumin ratio prognosis influencing factor overall survival rate |
| 基金项目:河北省自然科学基金（H2022206592，H2023206920）；河北省中医药管理局科研计划重点项目（Z2022017）；中央引导地方科技发展资金项目（236Z7726G）；河北医科大学第四医院科研创新团队支持计划（2023B10） |
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| 摘要点击次数: 53 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨中性粒细胞/白蛋白比值（neutrophil to albumin ratio，NAR）在胃癌术后患者中的临床价值。［方法］ 回顾性分析2018年1月1日至12月31日在河北医科大学第四医院行手术治疗的113例胃癌患者的临床资料。使用R软件“survminer”中的surv_cutpoint函数，计算NAR的最佳截断值。采用Kaplan-Meier生存曲线评价患者的总生存率，采用单因素、多因素Cox比例风险模型分析确定胃癌预后的影响因素，并采用受试者工作特征（receiver operating characteristic，ROC）曲线评估上述影响因素对胃癌患者术后总生存率的预测价值。［结果］ NAR的最佳截断值为0.101，113例胃癌患者中低NAR组60例，高NAR组53例。多因素分析结果显示，年龄［分险比（hazard ratio，HR）=1.061，95%置信区间（confidence interval，CI）：1.025~1.099，P<0.001］、TNM分期（HR=1.959，95%CI：1.048~3.661，P=0.035）、脉管癌栓（HR=1.980，95%CI：1.032~3.796，P=0.039）、NAR（HR=3.569，95%CI：1.240~10.271，P=0.018）是胃癌术后患者预后的独立影响因素。高NAR患者5年生存率为（50.9%）显著低于低NAR患者（73.3%）（P=0.012）。NAR预测胃癌术后患者总生存率的曲线下面积（area under the curve，AUC）为0.644（95%CI：0.539~0.749），NAR联合年龄、TNM分期、脉管癌栓预测总生存率的AUC则为0.846（95%CI：0.773~0.918）。［结论］ 高NAR是胃癌术后患者预后的独立危险因素，具有良好的临床应用价值。 |
| 英文摘要: |
| Abstract： ［Objective］ To investigate the clinical value of neutrophil to albumin ratio (NAR) in postoperative gastric cancer patients. ［Methods］ Clinical data of 113 gastric cancer patients who underwent surgical treatment in the Fourth Hospital of Hebei Medical University from January 1 to December 31， 2018 were collected and retrospectively analyzed. The optimal cut-off value of NAR was calculated by the surv_cutpoint function in R software “survminer”. The overall survival rate was evaluated by Kaplan-Meier survival curve. The influencing factors of gastric cancer prognosis was analyzed by univariate and multivariate Cox proportional hazards models， and the predictive value of these influencing factors on postoperative overall survival rate in gastric cancer patients was evaluated by receiver operating characteristic (ROC) curves. ［Results］ The optimal cut-off value for NAR was 0.101 ，there were 60 cases in the low NAR group and 53 cases in the high NAR group among 113 gastric cancer patients. Multivariate analysis showed that age［hazard ratio(HR)=1.061，95% confidence interval(CI)：1.025~1.099，P<0.001］， TNM stage(HR=1.959，95%CI：1.048~3.661，P=0.035)， lymphovascular invasion(HR=1.980，95%CI：1.032~3.796，P=0.039)， and NAR(HR=3.569，95%CI：1.240~10.271，P=0.018) were independent factors affecting the prognosis of postoperative gastric cancer patients. The 5-year overall survival rate in the low NAR group(73.3%) was significantly higher than that in the high NAR group(50.9%) (P=0.012). The area under the curve (AUC) of NAR for predicting the overall survival rate of postoperative gastric cancer patients was 0.644 (95%CI：0.539~0.749)， and the AUC of NAR combined with age， TNM stage， and lymphovascular invasion prediction for overall survival rate was 0.846(95%CI：0.773~0.918). ［Conclusion］ High NAR is an independent risk factor for poor prognosis in postoperative gastric cancer patients and has good clinical application value. |
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