| 中文关键词: 胃肿瘤 失巢凋亡 分子机制 信号通路 |
| 英文关键词:gastric neoplasms anoikis molecular mechanism signaling pathway |
| 基金项目:河北省自然科学基金（H2024206126） |
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| 摘要点击次数: 47 |
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| 中文摘要: |
| 摘 要：失巢凋亡是细胞与细胞外基质和其他细胞失去接触而诱导的一种特殊的程序化细胞死亡形式，对组织发育和机体平衡至关重要。肿瘤细胞会发展出非锚定条件下生存和生长的能力，称为失巢凋亡抵抗。研究失巢凋亡抵抗的相关机制可以明确对胃癌发生远处转移的认识，为胃癌的靶向治疗和精准治疗提供理论依据，为胃癌的治疗提供新的思路。全文总结失巢凋亡的相关分子机制和胃癌细胞获得失巢凋亡抗性的信号通路，分析失巢凋亡在胃癌治疗中的潜在价值、抑制失巢凋亡抵抗的意义以及胃癌失巢凋亡目前面临的挑战。 |
| 英文摘要: |
| Abstract： Anoikis is a special form of programmed cell death induced by the loss of contact between cells and the extracellular matrix or other cells， which is crucial for tissue development and homeostasis. Tumor cells develop the ability to survive and grow under detachment conditions， known as anoikis resistance. Studying the mechanisms related to anoikis resistance can enhance the understanding of distant metastasis in gastric cancer， providing a theoretical basis for targeted and precision therapy for gastric cancer and offering new therapeutic strategies. This paper summarizes the relevant molecular mechanisms of anoikis and the signaling pathways through which gastric cancer cells acquire anoikis resistance， and analyzes the potential value of anoikis in the treatment of gastric cancer， the significance of inhibiting anoikis resistance， and the current in challenges anoikis research for gastric cancer. |
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