| 李 勇,檀碧波,宋 超.进展期胃癌新辅助治疗现状与前景[J].肿瘤学杂志,2025,31(10):837-843. |
| 进展期胃癌新辅助治疗现状与前景 |
| The Current Status and Future Prospects of Neoadjuvant Treatment for Advanced Gastric Cancer |
| 投稿时间：2025-07-25 |
| DOI：10.11735/j.issn.1671-170X.2025.10.B002 |
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| 中文关键词: 胃肿瘤 进展期 新辅助治疗 免疫疗法 |
| 英文关键词:gastric neoplasms advanced stage neoadjuvant therapy immunotherapy |
| 基金项目:河北省省级科技计划（22377701D）；河北省自然科学基金（H2024206126）；河北医科大学“十四五”临床医学创新研究团队支持计划（2022-LCTD-A13） |
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| 中文摘要: |
| 摘 要：胃癌是一种恶性程度高、预后差的消化道恶性肿瘤，由于早期无特异性症状，大多数患者就诊时已处于进展期。局部进展期胃癌新辅助治疗的安全性和有效性已被多项研究证实，可以缩小肿瘤、提高手术切除率，改善患者的长期生存。新辅助化疗、免疫治疗、靶向治疗、细胞疗法等治疗方案的发展在临床研究中展现出良好的疗效和巨大潜力，为胃癌患者的治疗提供了更多选择。但胃癌新辅助治疗在方案选择、化疗耐药、相关不良反应等方面仍面临挑战。全文对进展期胃癌新辅助治疗的现状与前景进行分析。 |
| 英文摘要: |
| Abstract： Gastric cancer is a highly malignant tumor of the digestive tract with a poor prognosis. The lack of specific early symptoms often results in the majority of patients being diagnosed at an advanced stage. Neoadjuvant therapy for locally advanced gastric cancer has been demonstrated to be safe and effective by numerous studies， reducing tumor burden， increasing the rate of curative resection， and improving long-term survival. Various neoadjuvant modalities， including chemotherapy， immunotherapy， targeted therapy， and cellular therapy， have shown promising efficacy and significant potential in clinical research， expanding treatment options for patients. Nevertheless， challenges persist in optimizing treatment selection， overcoming chemotherapy resistance， and managing treatment-related adverse events. This paper comprehensively reviews the current status and future prospects of neoadjuvant therapy for locally advanced gastric cancer. |
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