| 张春暖,辛 鑫,李晓静,等.三阴性乳腺癌小分子靶向药物的应用与前景[J].肿瘤学杂志,2025,31(9):753-762. |
| 三阴性乳腺癌小分子靶向药物的应用与前景 |
| Application and Prospect of Small Molecule Targeted Drugs in the Treatment of Triple Negative Breast Cancer |
| 投稿时间：2024-12-14 |
| DOI：10.11735/j.issn.1671-170X.2025.09.B002 |
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| 中文关键词: 三阴性乳腺癌 小分子靶向药物 靶向治疗 临床试验 精准治疗 |
| 英文关键词:triple negative breast cancer small molecule targeted drugs targeted therapy clinical trial precision therapy |
| 基金项目:基金项目：北京医学奖励基金（YXJL-2020-1225-0323） |
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| 摘要点击次数: 165 |
| 全文下载次数: 76 |
| 中文摘要: |
| 摘 要：三阴性乳腺癌（triple negative breast cancer，TNBC）具有高侵袭性、易转移复发及预后差的特点，目前化疗仍是主要治疗手段。随着Lehmann分型的提出和对精准治疗的探索，针对各种膜受体、细胞信号通路组分、蛋白酶体以及一些其他靶标的小分子靶向药物受到广泛关注，其在三阴性乳腺癌治疗中各有表现；然而耐药问题显著，联合用药、研发新药等策略可能成为破局方向。全文对三阴性乳腺癌小分子靶向药物研究进展予以综述，剖析其作用机制、临床试验结果，并对未来研究方向作出展望。 |
| 英文摘要: |
| Abstract： Triple-negative breast cancer (TNBC) is characterized by high invasiveness， a tendency for metastasis and recurrence， and poorly prognosis. Chemotherapy remains the primary treatment modality. With the introduction of the Lehmann molecular classification and advances in precision therapy， small molecule targeted drugs directed at various membrane receptors， signaling pathway components， proteasomes， and other targets have garnered increasing interest， demonstrating varied efficacy in TNBC treatment. However， drug resistance remains a significant challenge. Strategies such as combination therapies and the development of novel agents may offer promising solutions. This paper summarizes recent progress on small molecule targeted drugs for TNBC， analyzes their mechanisms of action and clinical trial outcomes， and discusses future research directions. |
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