| 张珍珍,张俊丽,陈卓静,等.组蛋白去甲基化酶KDM3B在肿瘤中的作用研究进展[J].肿瘤学杂志,2025,31(8):732-739. |
| 组蛋白去甲基化酶KDM3B在肿瘤中的作用研究进展 |
| Research Progress on the Role of Histone Demethylase KDM3B in Tumors |
| 投稿时间：2024-11-22 |
| DOI：10.11735/j.issn.1671-170X.2025.08.B012 |
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| 中文关键词: 组蛋白 甲基化 KDM3B 表观遗传学 恶性肿瘤 治疗靶点 |
| 英文关键词:histone methylation KDM3B epigenetics neoplasms therapeutic targets |
| 基金项目:山西省运城市中心医院院级课题（YJ2022004） |
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| 中文摘要: |
| 摘 要：组蛋白甲基化和去甲基化修饰是表观遗传学广泛且重要的调控机制之一。其中，组蛋白赖氨酸甲基化和去甲基化与染色质抑制和激活密切相关，其甲基化活性不仅取决于赖氨酸残基被靶向的位点及甲基化程度，而且与赖氨酸甲基化发生的基因区域有关。目前，组蛋白H3的第9位赖氨酸（histone H3 lysine 9，H3K9）甲基化和去甲基化是研究最深入的组蛋白修饰之一，它被认为是转录沉默异染色质的表观遗传标志物。组蛋白去甲基化酶KDM3B是一种重要的表观遗传调控因子，它通过特异性去除H3K9的单甲基化和二甲基化（H3K9me1/2）修饰直接或间接招募转录因子形成相关复合体影响染色质结构和紧密度来调控基因的转录和表达。KDM3B可直接或间接抑制或促进肿瘤的发生。全文分析KDM3B的功能及在肿瘤发生与进展中作用及潜在治疗靶点，以期为开发新型表观遗传药物提供信息。 |
| 英文摘要: |
| Abstract： Among the epigenetic regulatory mechanisms， histone methylation and demethylation represent pivotal processes that modulate chromatin dynamics. Specifically， lysine methylation and demethylation are closely associated with chromatin repression or activation， with their functional outcomes are determined by the targeted lysine residue， methylation degree (mono-， di-， or tri-methylation)， and the genomic context of the modification. Histone H3 lysine 9 (H3K9) methylation and demethylation are among the most well-characterized histone modifications， as H3K9 methylation serves as an epigenetic hallmark of transcriptionally silenced heterochromatin. The histone lysine demethylase KDM3B has emerged as a key epigenetic regulator， which catalyzes the removal of mono- and di-methyl groups from H3K9 (H3K9me1/2)， thereby modulating chromatin architecture and compaction. This enzymatic activity enables KDM3B to directly or indirectly recruit transcriptional machinery and form regulatory complexes that govern gene transcription. KDM3B can inhibit or promote the occurrence of tumors directly or indirectly. This paper analyzes the function of KDM3B， its role in tumor occurrence and progression， and potential therapeutic targets， to provide information for the development of new epigenetic drugs. |
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