| 万雅琪,白 洁,陶凯雄.EZH2与消化系统肿瘤的关系及其作用机制的研究进展[J].肿瘤学杂志,2025,31(6):548-555. |
| EZH2与消化系统肿瘤的关系及其作用机制的研究进展 |
| Research Progress on Effects of EZH2 on Tumourigenesis and Progress of Digestive System Tumor and Its Mechanism |
| 投稿时间：2024-11-12 |
| DOI：10.11735/j.issn.1671-170X.2025.06.B011 |
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| 中文关键词: EZH2 表观遗传修饰 消化系统肿瘤 机制 抑制剂 |
| 英文关键词:EZH2 epigenetic modification digestive system cancer mechanism inhibitor |
| 基金项目:国家自然科学基金（82303510） |
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| 中文摘要: |
| 摘 要：消化系统肿瘤如食管癌、胃癌、肝癌、结直肠癌等的发病率在恶性肿瘤中均位居前列。传统治疗方法如手术治疗和放化疗在进展期肿瘤中治疗效果局限，远期预后较差。因此，针对消化系统肿瘤的新型靶向治疗正逐渐兴起。果蝇Zeste基因增强子人类同源物 2（enhancer of Zeste homolog 2，EZH2）作为表观遗传学的关键蛋白，在许多肿瘤中都高表达，其主要催化组蛋白H3第27位赖氨酸（histone H3 lysine 27，H3K27)发生三甲基化，这种催化功能在消化系统肿瘤中发挥重要作用，具有判断预后和作为治疗靶点的潜能。全文探讨了EZH2的作用机制以及其与消化系统肿瘤发生、预后的关系，分析EZH2在消化系统肿瘤免疫微环境、细胞周期、凋亡和迁移中的关键作用，并总结已应用于临床以及部分处于临床研究和基础研究阶段的EZH2抑制剂。 |
| 英文摘要: |
| Abstract： Digestive system cancers, including esophageal carcinoma, gastric cancer, hepatocellular carcinoma, and colorectal cancer, rank among the most prevalent malignancies in terms of incidence. Conventional therapeutic approaches, such as surgical resection, radiochemotherapy, exhibit limited efficacy in advanced-stage tumors and are associated with poor long-term prognosis, currently there is an emerging focus on the development of novel targeted therapies for digestive system tumors. Enhancer of Zeste homolog 2 (EZH2)， a pivotal epigenetic protein， is highly expressed in numerous tumors and predominantly catalyses the trimethylation of lysine at position 27 of histone H3(H3K27) which critically contributes to digestive system cancers and serves as a prognostic marker and therapeutic target. In this paper，the effect and mechanism of EZH2 on the tumourigenesis and progress of digestive tract malignant tumors are reviewed， the roles of EZH2 in the immune microenvironment， cell cycle， apoptosis and metastasis of digestive system tumors are analyzed， and the clinically available EZH2 inhibitors and those undergoing clinical and basic research are also summarized. |
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