| 李洁茹,马圣宇,李雪光,等.营养风险筛查2002评分、预后营养指数及控制营养状况评分对多发性骨髓瘤患者预后的影响[J].肿瘤学杂志,2025,31(6):516-522. |
| 营养风险筛查2002评分、预后营养指数及控制营养状况评分对多发性骨髓瘤患者预后的影响 |
| Association Between Nutrition Risk Screening 2002， Prognostic Nutritional Index and Controlling Nutritional Status with Prognosis of Patients with Multiple Myeloma |
| 投稿时间：2024-11-15 |
| DOI：10.11735/j.issn.1671-170X.2025.06.B007 |
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| 中文关键词: 多发性骨髓瘤 营养风险筛查2002 预后营养指数 控制营养状况 预后 |
| 英文关键词:multiple myeloma nutrition risk screening 2002 prognostic nutritional index controlling nutritional status prognosis |
| 基金项目:安徽省高等学校科学研究项目（2022AH050673） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨营养风险筛查2002（nutrition risk screening 2002，NRS 2002）评分、预后营养指数（prognostic nutritional index，PNI）及控制营养状况（controlling nutritional status，CONUT）评分与初诊多发性骨髓瘤（multiple myeloma，MM）患者临床特征的关系及其对预后的影响。［方法］ 回顾性分析2019年6月至2023年2月在安徽医科大学附属宿州医院首次确诊的70例MM患者的临床资料，分析不同 NRS 2002评分、PNI及CONUT评分组的临床特征差异，并采用 Kaplan-Meier 法及 Cox 比例风险回归模型进行患者总生存期的影响因素分析。［结果］ 不同NRS 2002评分及PNI组患者年龄、血红蛋白、体质指数、白蛋白及总胆固醇之间存在统计学差异（P均＜0.05），不同CONUT评分组患者年龄、浆细胞比例、白蛋白及总胆固醇均存在统计学差异（P均＜0.05）。Cox比例风险回归模型多因素分析显示：NRS 2002评分（HR=9.129，95%CI：2.072~40.299，P=0.003）、PNI（HR=0.119，95%CI：0.017~0.843，P=0.033）为影响MM患者总生存期的独立危险因素。［结论］ 高NRS 2002评分、低PNI通常提示MM患者不良预后，临床工作中应尽早地识别并进行营养干预。 |
| 英文摘要: |
| Abstract： ［Objective］ To explore the association of nutrition risk screening 2002(NRS 2002)， prognostic nutritional index(PNI) and controlling nutritional status(CONUT) with the prognosis of patients with multiple myeloma(MM). ［Methods］ The clinical datas of 70 patients with MM admitted in Suzhou Hospital of Anhui Medical University from June 2019 to February 2023 were analyzed retrospectively. The nutritional status of patients were assessed with NRS 2002 score， PNI and CONUT score. The prognosis of patients was evaluated with Kaplan-Meier method， and the association of NRS 2002 score， PNI and CONUT score with patients’ overall survival was analyzed by univariate and multivariate Cox proportional hazard regression model. ［Results］ There were significant differences in age， hemoglobin， body mass index， albumin and total cholesterol levels among patients with different NRS 2002 score and different PNI(all P<0.05)， and there were statistical differences in age， plasma cell ratio， albumin level and total cholesterol among patients with different CONUT score (all P<0.05). Multivariate Cox analysis showed that NRS 2002 score (HR=9.129， 95%CI： 2.072~40.299， P=0.003) and PNI (HR=0.119， 95%CI： 0.017~0.843， P=0.033) were independent influencing factors for the overall survival of patients with MM. ［Conclusion］ High NRS 2002 score and low PNI score generally indicate a poor prognosis in MM patients. |
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