| 李 慧,冯勤梅,乔锦阳.宫颈癌相关分子标记的多组学研究现状[J].肿瘤学杂志,2025,31(3):196-201. |
| 宫颈癌相关分子标记的多组学研究现状 |
| Current Status of Multi Omics Research on Molecular Markers of Cervical Cancer |
| 投稿时间：2024-12-02 |
| DOI：10.11735/j.issn.1671-170X.2025.03.B003 |
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| 中文关键词: 宫颈肿瘤 生物信息学 多组学分析 分子标志物 |
| 英文关键词:cervical neoplasms bioinformatics multi omics analysis molecular biomarker |
| 基金项目: |
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| 摘要点击次数: 66 |
| 全文下载次数: 9 |
| 中文摘要: |
| 摘 要：宫颈癌的早期诊断、精准治疗及预后评估是医学研究的核心挑战。全文基于多组学技术，总结了与宫颈癌相关的分子标志物。在基因组学层面，整合素β1作为低氧诱导因子1α的新下游靶点，其抗肿瘤潜力逐渐显现，而核受体相关蛋白1和三叶因子3高表达可能增加宫颈癌风险。此外，接触蛋白4也在多种恶性肿瘤的进展中扮演重要角色。蛋白组学中，桥粒斑蛋白、蛋白磷酸酶1调控亚基13样和钙磷脂结合蛋白A8与宫颈癌的转移息息相关，B细胞淋巴瘤/白血病-2蛋白、转录因子SMAD3和磷酸化位点T70则通过调控细胞凋亡影响着宫颈癌的进展，候选蛋白质生物标志物微染色体维持缺陷3和桥粒包斑蛋白基因可作为癌前筛查的潜在标志物。转录组学方面，CC基序趋化因子配体20和环粒蛋白激酶抑制剂2A在肿瘤中显著性上调，磷脂酰肌醇-4，5-二磷酸3-激酶催化亚基α突变和PI3K/AKT通路的异常激活在HPV阴性诱导型宫颈癌发生中扮演核心角色。代谢组学方面，2-甲基-1-丙胺与雌酮组合检测有助于宫颈癌的早期诊断，而葡萄糖-6-磷酸脱氢酶和三甲胺氧化物通过调节代谢途径影响宫颈癌进展。这些关键的分子标志物为疾病的早期诊断、精准治疗和预后评估奠定了坚实的基础。 |
| 英文摘要: |
| Abstract： Cervical cancer is one of the major malignant tumors in gynecology， and its early diagnosis， precise， and prognosis evaluation are the challenges of medical research. Recent genomic researches have revealed that integrin β1， as a new downstream target of hypoxia-inducible factor-1α may have antitumor potential， high expression of nuclear receptor related protein 1 and trefoil factor 3 may increase the risk of cervical cancer， contactin 4 may play an important role in the progression of various malignant tumors. Proteomics researches have shown that desmoplakin， protein phosphatase 1， regulatory (inhibitor) subunit 13-like， and annexin A8 are closely related to the metastasis of cervical cancer， while B-cell lymphoma/leukemia-protein， transcription factor SMAD3， and phosphorylation site T70 may be involved in the progression of cervical cancer by regulating apoptosis. Minichromosome maintenance protein 3 and envoplakin， may be used as potential markers for precancerous screening. Transcriptomics researches have found that CC motif chemokine ligand 20 (CCL20) and cyclin-dependent kinase inhibitor 2A are significantly upregulated in tumors， and mutations in phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha and abnormal activation of the PI3K/AKT pathway may play a central role in the development of HPV-negative inducible cervical cancer. In metabolomics， the combination of 2-methyl-1-propan and estrone detection were demonstrated to have a role in the early diagnosis of cervical cancer， while glucose-6-phosphate dehydrogenase and trimethylamine N-oxide were related to the progression of cervical cancer by regulating metabolic pathways. This paper reviews the recent progress of these molecular biomarkers related to cervical cancer based on multi-omics technology， which may be used for the early diagnosis， precise treatment and prognosis evaluation of cervical cancer. |
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