| 潘振良,王雍博,刘维辉,等.腹股沟淋巴结清扫联合腹腔镜盆腔淋巴结清扫对cN1/2期阴茎癌患者的临床疗效和安全性[J].肿瘤学杂志,2025,31(2):163-167. |
| 腹股沟淋巴结清扫联合腹腔镜盆腔淋巴结清扫对cN1/2期阴茎癌患者的临床疗效和安全性 |
| Efficacy and Safety of Inguinal Lymph Node Dissection Combined with Laparoscopic Pelvic Lymph Node Dissection for Patients with cN1/2 Penile Cancer |
| 投稿时间：2024-10-25 |
| DOI：10.11735/j.issn.1671-170X.2025.02.B012 |
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| 中文关键词: 阴茎肿瘤 腹股沟淋巴结清扫 盆腔淋巴结清扫 腹腔镜 临床疗效 安全性 |
| 英文关键词:penile neoplasms inguinal lymph node dissection pelvic lymph node dissection laparoscopic efficacy safety |
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| 中文摘要: |
| 摘 要：［目的］ 探讨腹股沟淋巴结清扫（inguinal Lymph node dissection，ILND）联合腹腔镜盆腔淋巴结清扫（laparoscopic pelvic lymph node dissection，LPLND）在cN1/2期阴茎癌患者中的临床疗效和安全性。［方法］回顾性分析2013年4月至2019年6月在福建医科大学附属第二医院接受手术并确诊为cN1/2期阴茎癌的32例患者的临床资料。对照组14例患者接受单纯ILND，观察组18例患者接受ILND+LPLND。比较两组围手术期指标、5年总生存率和术后并发症发生率。［结果］观察组手术时间［（176.2±12.0） min vs （132.1±9.5） min］和术中出血量［（63.8±7.9） mL vs （37.9±5.5） mL ］均显著高于对照组（P＜0.001），两组术后住院时间差异无统计学意义［（9.5±1.5） d vs （9.1±1.6） d，P=0.53］。观察组患者的5年生存率为22%，显著高于对照组的7%（P=0.035）。两组术后各并发症（切口疼痛、切口感染、皮肤坏死、淋巴瘘）发生率差异均无统计学意义（P＞0.05）。［结论］ ILND+LPLND可提高cN1/2期阴茎癌患者的生存率，且未增加并发症发生率，可在临床推广使用。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the efficacy and safety of inguinal lymph node dissection(ILND) combined with laparoscopic pelvic lymph node dissection (LPLND) for patients with cN1/2 penile cancer. ［Methods］ The clinical data of 32 patients with stage cN1/2 penile cancer who underwent surgery in the Second Affiliated Hospital of Fujian Medical University from April 2013 to June 2019 were retrospectively analyzed， including 14 cases receiving INLD only (control group) and 18 cases receiving INLD+LPLND (observation group) . The perioperative indexes， 5-year overall survival and incidence of postoperative complications were compared between the two groups.［Results］ The operative time［(176.2±12.0) min vs (132.1±9.5) min］ and intraoperative blood loss［(63.8±7.9) mL vs (37.9±5.5) mL］ in observation group were significantly higher than those in control group (P<0.001)， but there was no significant difference in postoperative hospital stay between two groups ［(9.5±1.5) d vs (9.1±1.6) d， P=0.53］. The 5-year overall survival of the observation group patients was significantly higher than that of the control group(22% vs 7%， P=0.035). There was no statistically significant difference in the incidence of postoperative complications (incision pain， incision infection， skin necrosis， lymphatic fistula) between the two groups (P>0.05). ［Conclusion］ ILND combined with LPLND can improve the survival of patients with cN1/2 penile cancer without increasing the incidence of complications， which is worth promoting clinically. |
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