武新翔,阮 峥,侯孟森,等.E3泛素连接酶和去泛素化酶在肝细胞癌中的研究进展[J].肿瘤学杂志,2025,31(1):59-65. |
E3泛素连接酶和去泛素化酶在肝细胞癌中的研究进展 |
Research Progress on E3 Ubiquitin Ligases and Deubiquitinating Enzymes in Hepatocellular Carcinoma |
投稿时间:2024-06-04 |
DOI:10.11735/j.issn.1671-170X.2025.01.B009 |
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中文关键词: 肝细胞癌 泛素-蛋白酶体途径 E3泛素连接酶 去泛素化酶 |
英文关键词:hepatocellular carcinoma ubiquitin-proteasome pathway E3 ubiquitin ligase deubiquitinating enzyme |
基金项目:国家卫健委胃肠肿瘤诊治重点实验室博士基金项目(NHCDP2022001);博士研究生导师培育项目(ZX-62000001-2022-193);甘肃省卫生行业科研计划项目(GSWSKY2020-45);甘肃省自然科学基金(20JR10RA378);甘肃省卫生行业科研计划项目(GSWSKY2021-060);兰州市城关区科技计划项目(2023SHFZ0015) |
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中文摘要: |
摘 要:泛素-蛋白酶体途径(ubiquitin-proteasome pathway,UPP)是人体内蛋白质的主要降解途径,不同于其他致癌因子的作用机制,该途径导致肝细胞癌(hepatocllular carcinoma,HCC)进展的机制与泛素化和去泛素化酶失调有关。全文综述E3泛素连接酶和泛素特异性蛋白酶(ubiquitin specific peptidase,USP)家族成员在HCC发生及进展中的作用,包括E3泛素连接酶通过影响 HCC 增殖、迁移、侵袭、细胞周期、代谢重编程和耐药性等发挥双重作用,USP家族成员可通过介导HCC相关信号通路的激活、铁死亡抗性、耐药性、恶性表型,或与底物相互促进影响HCC进展,并阐明了相关作用机制,为今后开发潜在的HCC靶向生物药品提供借鉴,以期提高HCC远期治疗效果并改善预后。 |
英文摘要: |
Abstract: The ubiquitin-proteasome pathway(UPP) is the major protein degradation pathway in humans. In contrast to other oncogenic factors, the mechanism of UPP involving in hepatocellular carcinoma(HCC) progression is associated with dysregulation of ubiquitination and deubiquitination, in which ubiquitin E3 ligase and ubiquitin specific peptidase(USP) family play important roles. The E3 ubiquitin ligase has a dual role affecting HCC proliferation, migration, invasion, cell cycle, metabolic reprogramming, and drug resistance. While USP family members influence HCC progression by mediating the activation of HCC-related signaling pathways, iron death resistance, drug resistance, malignant phenotype, or reciprocal promotion with substrates. This paper elucidates the roles of E3 ligase and USP family in the occurrence and development of HCC and the relevant mechanisms, to provide reference for the development of potential HCC-targeted biological drugs. |
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