| 龙 渺,钱 云,俞 浩,等.心脏代谢指数与乳腺癌发病风险的关联性研究[J].肿瘤学杂志,2025,31(1):30-35. |
| 心脏代谢指数与乳腺癌发病风险的关联性研究 |
| Association Between Cardiometabolic Index and Risk of Breast Cancer |
| 投稿时间：2024-08-30 |
| DOI：10.11735/j.issn.1671-170X.2025.01.B005 |
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| 中文关键词: 心脏代谢指数 乳腺肿瘤 病例对照研究 相关性 |
| 英文关键词:cardiometabolic index breast neoplasms case-control study association |
| 基金项目:世界癌症研究基金会项目（WCRF 2011/RFA/473） |
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| 中文摘要: |
| 摘 要：［目的］ 探索心脏代谢指数（cardiometabolic index，CMI）与乳腺癌发病风险的关联。［方法］ 基于在江苏省无锡市开展的女性乳腺癌病例对照研究，病例组为2013年11月至2014年11月确诊原发性乳腺癌患者，对照组为来自同一地区、年龄±5岁、无癌症病史的女性。研究共纳入796例乳腺癌病例和930名健康对照。研究对象中位年龄53.00岁，65.64%已绝经。按照绝经状态进行分层，采用多因素条件Logistic回归模型分析总人群、未绝经和已绝经女性中CMI与乳腺癌发病风险的关联，并计算比值比（odds ratio，OR）及其95%可信区间（confidence interval，CI）。采用4个节点的限制性立方样条分别拟合CMI与乳腺癌发病风险的剂量反应关系。［结果］ 多因素条件Logistic回归分析结果显示，在调整混杂因素后，CMI水平每增加一个分组层级，总人群、未绝经和已绝经女性中乳腺癌发病风险分别增加133.0%（OR=2.330，95%CI：1.919~2.861）、176.8%（OR=2.768，95%CI：1.861~4.302）和116.6%（OR=2.166，95%CI：1.745~2.729）。CMI水平与乳腺癌发病风险之间存在非线性正向剂量反应关系（均P总趋势<0.001）。CMI与乳腺癌发病风险的关联在年龄≤60岁和低体力活动水平亚组中更强。［结论］ CMI水平升高与乳腺癌发病风险增加有关，未来仍需在前瞻性研究中予以验证。 |
| 英文摘要: |
| Abstract：［Objective］ To analyze the association between cardiometabolic index(CMI) and risk of breast cancer. ［Methods］ Clinical data of 796 female patients with primary breast cancer diagnosed between November 2013 and November 2014 were collected from Wuxi Cancer Network Report System as case group and 930 age-matched healthy women randomly selected from local population electronic health record database as control group. The median age of the participants was 53.00 years old and 65.64% participants were postmenopausal women. The multivariate conditional Logistic regression models were applied to analyze the association between CMI and breast cancer risk in the total participants， premenopausal and postmenopausal women， respectively. The restricted cubic spline analysis was used to assess the dose-response relationship between CMI and breast cancer risk. ［Results］ Multivariate conditional Logistic regression analysis showed that after adjusting for confounding factors， the risk of breast cancer in the all participants， premenopausal and postmenopausal women increased by 133.0% (OR=2.330， 95%CI：1.919~2.861)， 176.8% (OR=2.768， 95%CI：1.861~4.302) and 116.6% (OR=2.166， 95%CI：1.745~2.729) for each one-unit increase in CMI levels， respectively. There was a positive nonlinear dose-response relationship between CMI and breast cancer risk(all P trend < 0.001). The association between CMI and breast cancer was stronger in the subgroups of individuals aged ≤60 years old and with low levels of physical activity. ［Conclusion］ CMI levels are associated with the risk of breast cancer， which needs to be validated in future prospective studies. |
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