| 中文关键词: 软组织肉瘤 免疫治疗 免疫检查点抑制剂 过继性细胞疗法 肿瘤疫苗 肿瘤微环境 |
| 英文关键词:soft tissue sarcoma immunotherapy immune checkpoint inhibitors adoptive cell therapy tumor vaccine tumor microenvironment |
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| 摘要点击次数: 51 |
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| 中文摘要: |
| 摘 要： 软组织肉瘤是一组发病率低，高度异质性的恶性肿瘤，分型复杂。其主要治疗手段为手术治疗及化疗，但疗效有限。免疫治疗作为近年研究热点，在晚期软组织肉瘤的治疗中也开展了广泛探索。临床研究显示，免疫检查点抑制剂、过继性细胞疗法及肿瘤疫苗等免疫治疗在软组织肉瘤的治疗中取得了初步进展，但不同组织学类型的软组织肉瘤疗效差异显著。软组织肉瘤的多样性限制了该疾病免疫治疗的普遍方法。全文对软组织肉瘤中肿瘤微环境、肿瘤突变负荷等对免疫治疗障碍的分析，以期为进一步研究提供方向。 |
| 英文摘要: |
| Abstract： Soft tissue sarcomas are a group of malignant tumors with low incidence， high heterogeneity and complex typing. Surgical treatment and chemotherapy are the mainstay of therapy for soft tissue sarcomas， but they have limited efficacy. Immunotherapy， as a research hotspot in recent years， has also been extensively explored in the treatment of advanced soft tissue sarcomas. Clinical studies have shown that immune checkpoint inhibitors， adoptive cell therapy and tumor vaccines have made initial progress in the treatment of soft tissue sarcomas， but there are significant discrepancies in efficacy for different histological types of soft tissue sarcomas. The diversity of soft tissue sarcomas limits the universal approach of immunotherapy for the disease. The paper analyzes the impact of tumor microenvironment and tumor mutational load on efficacy of immunotherapy for soft tissue sarcomas， and discusses the directions of further studies. |
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