| 吴 寒,常 靓,宋彦茹,等.藿朴夏苓汤对进展期胃癌术后行替吉奥治疗患者营养状态相关指标的影响[J].肿瘤学杂志,2024,30(10):805-810. |
| 藿朴夏苓汤对进展期胃癌术后行替吉奥治疗患者营养状态相关指标的影响 |
| Effect of Chinese Medicine Huopoxialing Decoction on Nutritional Status in Patients with Advanced Gastric Cancer Undergoing Tigio Therapy and Postoperative Adjuvant Chemotherapy |
| 投稿时间：2024-06-17 |
| DOI：10.11735/j.issn.1671-170X.2024.10.B002 |
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| 中文关键词: 胃肿瘤 藿朴夏苓汤 辅助化疗 营养状态 |
| 英文关键词:gastric neoplasms Huopoxialing Decoction adjuvant chemotherapy nutritional status |
| 基金项目:河北省自然科学基金联合基金项目（H2022206592）；河北省科技厅重点研发计划（22377701D）；河北医科大学“十四五”临床医学创新研究团队支持计划（2022LCTD-A13）；河北省2022年政府资助省级医学优秀人才项目（冀财预复〔2022〕180 号）；河北省2023年度医学科学研究课题（20230123）；2022年度河北省医学适用技术跟踪项目（GZ2022044） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨藿朴夏苓汤联合替吉奥口服对接受辅助化疗的进展期胃癌术后患者营养状态相关指标的影响。［方法］ 收集30例接受藿朴夏苓汤联合替吉奥治疗的进展期胃癌术后患者治疗前后的营养指标资料作为研究组，以同期接受替吉奥单药口服的30例患者为对照组。回顾性分析2组患者用药前后的各项指标变化情况。2组患者均接受胃癌根治术，于术后4周开始用药，于用药前及用药第8周期结束1周时检测患者一般情况及营养状态相关指标：包括体质指数、外周血白细胞、中性粒细胞、血红蛋白、血小板及白蛋白、前白蛋白数值；比较2组不良反应发生情况（包括消化道不良反应、骨髓抑制、脱发等）。同时检测30例健康体检者（健康组）的上述各项指标。［结果］ 2组患者用药前的各项指标与健康组比较差异均有统计学意义（P均<0.05）。研究组与对照组在用药前各项营养指标无明显差异（P>0.05）；用药后，研究组中性粒细胞的水平明显下降，与用药前相比较差异有统计学意义（P＜0.05），而对照组体质指数、白细胞、中性粒细胞、白蛋白和前白蛋白的水平与化疗前相比较均明显降低（P＜0.05）。研究组患者的不良反应发生率明显低于对照组（P<0.05）。［结论］ 进展期胃癌患者术后应用藿朴夏苓汤能减轻替吉奥的不良反应并改善患者营养状况。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the effects of Chinese medicine Huopoxialing Decoction on nutritional status in patients with advanced gastric cancer undergoing Tigio therapy and postoperative adjuvant chemotherapy. ［Methods］ A total of 30 patients with advanced gastric cancer who underwent adjuvant chemotherapy 4 weeks after radical gastrectomy were enrolled in the study， including 30 cases receiving Huopoxialing Decoction and Tigio (study group) and 30 cases receiving Tigio monotherapy (control group)； and 30 healthy subjects were enrolled as healthy control group. The general conditions and nutritional indexes before and after medication were compared between two groups， including body mass index(BMI)， peripheral white blood cell(WBC)， neutrophil (NEUT)， hemoglobin (HB)， platelet (PLT)， albumin (ALB) and prealbumin (PA). The occurrence of adverse reactions (gastrointestinal adverse reactions， bone marrow suppression， alopecia， etc.) was also compared between the two groups. ［Results］ Before medication there were significant differences in all nutritional indices between 2 cancer groups and the healthy group (all P<0.05)； while there were no significant differences between the study group and the control group(P>0.05). After medication， the levels of BMI， WBC， NEUT， ALB， and PA in the control group decreased significantly compared to those before medication(P<0.05)； while for study group only the levels of NEUT were decreased (P<0.05). The incidence of adverse reactions in the study group was significantly lower than that in the control group (P<0.05). ［Conclusion］ Chinese medicine Huopoxialing Decoction can improve the nutritional status and alleviate adverse reactions in patients with advanced gastric cancer receiving tigio therapy and postoperative adjuvant chemotherapy. |
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