| 黄志洪,王 玲,薛 岩,等.RGD肽类似物应用于恶性黑色素瘤诊疗的研究进展[J].肿瘤学杂志,2024,30(7):611-617. |
| RGD肽类似物应用于恶性黑色素瘤诊疗的研究进展 |
| Advances on RGD Peptide Analogs for Diagnosis and Therapy of Malignant Melano |
| 投稿时间：2024-03-30 |
| DOI：10.11735/j.issn.1671-170X.2024.07.B012 |
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| 中文关键词: 恶性黑色素瘤 整合素 RGD肽类似物 早期诊断 靶向治疗 |
| 英文关键词:malignant melanoma integrin RGD peptide analogues early diagnosis targeted therapy |
| 基金项目:江苏省中医药科技发展计划项目（MS2023166）；江苏省卫生健康委科研项目（H2023150）；无锡市卫生健康委科研项目（Z202303） |
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| 中文摘要: |
| 摘 要：恶性黑色素瘤是一种高度恶性且易于转移的致命癌症，其预后与肿瘤早期诊断及精准治疗密切相关。整合素的异常表达与恶性黑色素瘤的发生及进展密切相关，介导了肿瘤的增殖、侵袭和转移，并与不良预后密切相关。以精氨酸-甘氨酸-天冬氨酸（Arg-Gly-Asp，RGD） 为基序的RGD肽类似物可特异性结合整合素，从而实现肿瘤的精准诊疗。全文基于RGD肽类似物的来源和分类，对其应用于恶性黑色素瘤诊疗的研究进展展开综述。 |
| 英文摘要: |
| Abstract： Malignant melanoma is a highly aggressive cancer characterized by high rates of metastasis and mortality. The prognosis of malignant melanoma is closely related to early diagnosis and accurate treatment. The abnormal expression of integrins occurs during the development and progression of malignant melanoma， which mediated tumor proliferation， invasion， and metastasis， and is closely associated with a poor prognosis. RGD peptide analogs， which utilize the arginine-glycine-aspartate(Arg-Gly-Asp) motif， can specifically bind to integrins， facilitating accurate diagnosis and targeted treatment of malignant tumors. This paper reviews the research advances on the sources and classification of RGD peptide analogs and their application in diagnosis and treatment of malignant melanoma. |
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