| 史敏敏,雷俊梅,崔萌萌,等.外周血白细胞介素-6水平联合CD4+/CD8+比值评估胃癌严重程度和预测复发的临床价值分析[J].肿瘤学杂志,2024,30(7):599-603. |
| 外周血白细胞介素-6水平联合CD4+/CD8+比值评估胃癌严重程度和预测复发的临床价值分析 |
| Serum IL-6 Level Combined with CD4+/CD8+ Ratio in Evaluate Severity and Predicting Recurrence of Gastric Cancer |
| 投稿时间：2023-11-15 |
| DOI：10.11735/j.issn.1671-170X.2024.07.B010 |
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| 中文关键词: 白细胞介素-6 CD4+/CD8+比值 胃肿瘤 复发 |
| 英文关键词:interleukin-6 CD4+/CD8+ ratio gastric neoplasms recurrence |
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| 摘要点击次数: 171 |
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| 中文摘要: |
| 摘 要： ［目的］ 分析外周血白细胞介素-6（interleukin-6，IL-6）水平联合CD4+/CD8+比值评估胃癌严重程度和预测复发的临床价值。［方法］ 选择2015年3月至2018年4月收治的120例胃癌患者为研究组，同期选择60名门诊健康体检者为对照组，对比两组的外周血IL-6水平、CD4+/CD8+比值，并对不同临床特征胃癌患者的外周血IL-6水平、CD4+/CD8+比值进行比较分析。随访5年，根据胃癌患者的复发情况进行分组，分析两组的外周血IL-6水平、CD4+/CD8+比值。采用受试者工作特征（receiver operating characteristic，ROC）曲线分析外周血IL-6水平联合CD4+/CD8+比值评估胃癌复发情况的临床价值。［结果］ 研究组的外周血IL-6水平明显高于对照组，CD4+/CD8+比值明显低于对照组（P均＜0.001）。不同TNM分期、分化程度、淋巴结转移胃癌患者的外周血IL-6水平、CD4+/CD8+比值比较差异均有统计学意义（P均＜0.001）。复发组（13例）的外周血IL-6水平明显高于未复发组（107例），CD4+/CD8+比值明显低于未复发组（P均＜0.001）。ROC曲线结果显示，IL-6的曲线下面积为0.771，CD4+/CD8+的曲线下面积为0.720，两者联合的曲线下面积为0.835（P＜0.001）。［结论］ 外周血IL-6水平高、低CD4+/CD8+比值与胃癌患者的病情严重程度相关。两者联合检测可作为预测胃癌复发的有效监测指标。 |
| 英文摘要: |
| Abstract： ［Objective］ To analyze the clinical value of serum IL-6 level and CD4+/CD8+ ratio in evaluate severity and predicting recurrence of gastric cancer. ［Methods］ A total of 120 patients with gastric cancer admitted from March 2015 to April 2018 were enrolled， and 60 healthy subjects were selected as controls. The serum IL-6 and CD4+/CD8+ ratio of the two groups were compared； and their correlation with clinicopathological features of gastric cancer patients were analyzed. Patients were followed up for 5 years， the IL-6 level and CD4+/CD8+ ratio were compared between patients with or without recurrence. The receiver operating characteristic (ROC) curve was used to analyze the value of IL-6 level combined with the ratio of CD4+/CD8+ in predicting recurrence of gastric cancer. ［Results］ Compared with healthy controls， the IL-6 level was significantly higher and the CD4+/CD8+ ratio was lower in the gastric cancer patients (all P<0.001). There were significant differences in IL-6 levels and CD4+/CD8+ ratio among gastric cancer patients with different TNM stages， differentiation levels， and status of lymph node metastasis (all P<0.001). The IL-6 levels in the recurrent group (n=13) were significantly higher， and the CD4+/CD8+ ratio was significantly lower than those in the non-recurrent group (n=107) (all P<0.001). ROC curve showed that the areas under the curve (AUC) of IL-6， CD4+/CD8+ and combination of two indicators were 0.771， 0.720 and 0.835， respectively (P<0.001). ［Conclusion］ The high serum IL-6 level and the low CD4+/CD8+ ratio are associated with the severity of gastric cancer patients； combined detection of both may serve as a monitoring indicator for predicting gastric cancer recurrence. |
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