| 叶彤彤,董晶晶,朱利明,等.功能性神经内分泌肿瘤诊治研究进展[J].肿瘤学杂志,2024,30(5):360-364. |
| 功能性神经内分泌肿瘤诊治研究进展 |
| Progress on Diagnosis and Treatment of Functional Neuro-endocrine Neoplasm |
| 投稿时间：2024-02-27 |
| DOI：10.11735/j.issn.1671-170X.2024.05.B002 |
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| 中文关键词: 功能性神经内分泌肿瘤 胰岛素瘤 胃泌素瘤 类癌综合征 |
| 英文关键词:functional neuroendocrine neoplasm insulinoma gastrinoma carcinoid syndrome |
| 基金项目:国家重点研发计划资助（2021YFA1301100，2021YFA1301104） |
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| 中文摘要: |
| 摘 要：神经内分泌肿瘤（neuroendocrine neoplasm，NEN）是一类起源于神经内分泌细胞和肽能神经元的罕见肿瘤。功能性神经内分泌肿瘤（functional neuroendocrine neoplasm，F-NEN）可以通过合成并分泌大量的肽、胺等相关激素，引起特异性临床表现，严重影响患者健康。F-NEN具有高度异质性，诊断困难且复杂，临床管理既需改善临床表现和控制肿瘤进展，又要实施个性化治疗。近年来，基于特异性靶点如生长抑素受体在临床诊疗研究中取得了突破性进展，为晚期NEN患者带来了生存希望。全文对F-NEN进行梳理，综述其诊断及治疗进展。 |
| 英文摘要: |
| Abstract： Neuroendocrine neoplasm(NEN) is a type of rare neoplasm originated from neuroendocrine cells and peptide-energetic neurons. Functional neuroendocrine neoplasm(F-NEN) can synthesize and secrete a large amount of peptides， amines and other related hormones， causing specific clinical manifestations and seriously affecting the health of patients. F-NEN is highly hete-rogeneous， the diagnosis of which is difficult and complex. The clinical management of F-NEN includes both improvement of clinical symptoms and control of tumor progression， therefor persona-lized treatment is required. In recent years， breakthroughs have been made in clinical diagnosis and treatment based on specific targets， such as somatostatin receptor(SSTR)， which brings survival benefit for patients with advanced NEN. In this paper，the progress on the diagnosis and treatment of F-NEN is reviewed. |
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