| 谢 娴,姚 烨,邓 伟.伦勃朗视觉感受图像影像指标在较低级别胶质瘤患者中的分布特征[J].肿瘤学杂志,2024,30(2):133-140. |
| 伦勃朗视觉感受图像影像指标在较低级别胶质瘤患者中的分布特征 |
| Distribution Characteristics of Visually Accessible Rembrandt Images Features in Patients with Lower-Grade Glioma |
| 投稿时间：2023-11-12 |
| DOI：10.11735/j.issn.1671-170X.2024.02.B007 |
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| 中文关键词: 胶质瘤 伦勃朗视觉感受图像 异柠檬酸脱氢酶 磁共振成像 |
| 英文关键词:glioma Visually Accessible Rembrandt Images isocitrate dehydrogenase magnetic resonance imaging |
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| 中文摘要: |
| 摘 要：［目的］ 分析WHO 2~3级胶质瘤患者的伦勃朗视觉感受图像（Visually Accessible Rembrandt Images，VASARI）特征总分水平，比较不同级别的VASARI特征分布，探索胶质瘤患者分级的潜在预测因素，帮助临床识别和管理。［方法］ 回顾性收集2011—2018年在复旦大学附属华山医院经病理确诊的95例WHO 2~3级（2级64例，3级31例）胶质瘤患者的分子标志物及影像资料。利用SAS 9.4软件比较不同级别胶质瘤患者间VASARI总分和各影像特征的分布差异。［结果］ 95例胶质瘤患者平均年龄44.0±11.24岁，其中男性50例（52.63%）。WHO 3级胶质瘤患者（中位数：66.00分）的VASARI总分显著高于WHO 2级胶质瘤患者（中位数：55.00分）的VASARI总分（Z=4.23，P<0.001）。异柠檬酸脱氢酶（isocitrate dehydrogenase，IDH）状态、O6-甲基鸟嘌呤-DNA甲基转移酶（O6-methylguanine DNA methyltransferase，MGMT）状态、强化程度、增强比例、非增强比例、坏死比例、是否囊变、T1WI与FLAIR 图像异常信号面积比、增强边缘厚度、增强边缘定义、非增强边缘定义、水肿比例、水肿穿过中线、深部白质入侵、增强肿瘤穿过中线、肿瘤大小等特征在WHO 2级与3级胶质瘤患者间分布差异均具有统计学意义（P均<0.05）。 ［结论］ WHO 2级与3级胶质瘤患者的VASARI总分和影像特征分布差异明显，与增强、非增强、囊变、坏死、水肿和肿瘤大小相关的影像特征是胶质瘤患者分级的相关因素。 |
| 英文摘要: |
| Abstract：［Objective］ To analyze and compare the level and distribution characteristics of the Visually Accessible Rembrandt Images (VASARI) feature score in patients glioma (WHO grade 2-3) and to explore potential predictors of glioma grading， aiding clinical identification and management. ［Methods］ Molecular markers and imaging data of 95 patients pathologically diagnosed as WHO grade 2-3 glioma (64 WHO grade 2 and 31 WHO grade 3) in Huashan Hospital of Fudan University from 2011 to 2018 were retrospectively collected. The differences in the total VASARI score and the distribution of imaging features between patients with different grades of glioma were compared separately using SAS 9.4 software. ［Results］ The mean age of the 95 subjects was 44.00±11.24 years old， of which 50 (52.63%) were male. The total VASARI score was significantly higher (Z=4.23， P<0.001) in patients with WHO grade 3 glioma (median： 66.00) than those in patients with WHO grade 2 glioma (median： 55.00). The distribution of isocitrate dehydrogenase (IDH) status， O6-methylguanine DNA methyltransferase (MGMT) status， enhancement quality， proportion of enhancing tumor， proportion of non-enhancing tumor， proportion of necrosis， cyst， T1/FLAIR ratio， the thickness of enhancing margin， the definition of enhancing margin， the definition of non-enhancing margin， proportion of edema， edema crosses the midline， deep white matter invasion， enhancing tumor crosses the midline， and lesion size were statistically significant between patients with grade 2 and grade 3 glioma(P<0.05). ［Conclusion］ The total VASARI scores and the distribution of imaging features were statistically significant between grade 2 and grade 3 glioma patients， with imaging features related to enhancement， non-enhancement， cyst， necrosis， edema， and lesion size being relevant factors in grading glioma patients. |
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