| 王佳惠,黄月雨,姚其峰,等.胸腺上皮肿瘤微环境异常与自身免疫障碍发生的研究进展[J].肿瘤学杂志,2024,30(1):63-68. |
| 胸腺上皮肿瘤微环境异常与自身免疫障碍发生的研究进展 |
| Progress on Abnormal Immune Microenvironment and Thymic Epithelial Tumors |
| 投稿时间：2023-06-14 |
| DOI：10.11735/j.issn.1671-170X.2024.01.B011 |
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| 中文关键词: 胸腺上皮肿瘤 免疫微环境 淋巴细胞发育 自身免疫性疾病 |
| 英文关键词:thymic epithelial tumors immunological microenvironment lymphocyte development autoimmune diseases |
| 基金项目:国家自然科学基金面上项目资助(82172567)；江西省重点研发项目(20212BBG71006) |
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| 中文摘要: |
| 摘 要：胸腺是T淋巴细胞发育及T细胞受体形成的重要器官，在适应性免疫和中枢耐受建立中发挥关键作用。祖T细胞在早期发育阶段由骨髓迁移至胸腺，经过与皮质及髓质区的胸腺上皮细胞相互作用，先凭借阳性选择再通过阴性选择分化为成熟T淋巴细胞，共同形成了胸腺独特的微环境。胸腺上皮肿瘤是前纵隔中常见的原发性肿瘤，异常增殖的上皮细胞常伴随大量的未成熟的淋巴细胞，造成自身免疫性临床症状，但其确切的分子调控机制与形成机制尚不清楚。全文综述胸腺上皮肿瘤微环境异常与自身免疫障碍发生的研究进展。 |
| 英文摘要: |
| Abstract： The thymus is an important organ for T lymphocyte development and the formation of T-cell receptors， playing a critical role in adaptive immunity and central tolerance establishment. Progenitor T cells migrate from the bone marrow to the thymus during early developmental stages and interact with thymic epithelial cells in the cortical and medullary regions of thymus. Through positive and negative selection processes， these progenitor T cells differentiate into mature T lymphocytes， contributing to the unique microenvironment of the thymus. Thymic epithelial tumors are common primary tumors in the anterior mediastinum， characterized by the abnormal proliferation of epithelial cells often accompanied by a large number of immature lymphocytes， which can potentially lead to autoimmune clinical symptoms. However， the exact molecular regulatory mechanisms and the underlying pathogenesis of these tumors remain unclear. This paper reviews the research progress on the disruption of immune microenvironment in tymus during the occurrence and development of thymic epithelial tumors. |
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