| 沈海幸,尚 希,卢越新,等.乳腺癌合并2型糖尿病226例临床病理特征及预后分析[J].肿瘤学杂志,2024,30(1):32-37. |
| 乳腺癌合并2型糖尿病226例临床病理特征及预后分析 |
| Clinicopathologic Features and Prognosis of 226 Cases of Breast Cancer Complicated with Type 2 Diabetes Mellitus |
| 投稿时间：2023-01-03 |
| DOI：10.11735/j.issn.1671-170X.2024.01.B007 |
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| 中文关键词: 2型糖尿病 乳腺癌 无病生存 乳腺癌特异性生存 |
| 英文关键词:type 2 diabetes mellitus breast cancer disease-free survival breast cancer specific survival |
| 基金项目:慈溪市公益类科技计划资助项目（CN2021009） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨乳腺癌合并2型糖尿病患者临床病理特征及预后特点。［方法］ 从2015—2018年浙江大学附属第一医院乳腺癌手术队列中筛选乳腺癌合并2型糖尿病226例和随机抽取的无糖尿病乳腺癌788例，比较两组患者的临床病理特征；对两组数据进行1∶1倾向性评分匹配后，Kaplan-Meier方法分析两组无病生存率及乳腺癌特异性生存率；采用Cox回归分析2型糖尿病对乳腺癌无病生存率及乳腺癌特异性生存率的影响。［结果］ 乳腺癌合并2型糖尿病患者的肿瘤体积相对较大、病理组织学分级较高，无病生存率及乳腺癌特异性生存期较短。多因素Cox回归分析显示，2型糖尿病是乳腺癌术后复发的独立预后因素（HR=1.760，95%CI：1.101~2.672），也是乳腺癌特异性死亡的独立预后因素（HR=1.724，95%CI：1.018~3.122）。 ［结论］合并2型糖尿病的乳癌患者预后较差，建议制定个体化治疗方案和更多关注。 |
| 英文摘要: |
| Abstract： ［Objective］ To analyze the clinicopathological features and prognosis of invasive breast cancer patients complicated with type 2 diabetes mellitus(T2DM). ［Methods］ Among breast cancer patients treated in Department of Breast Surgery， the First Affiliated Hospital of Zhejiang University School of Medicine from 2015 to 2018， 226 cases were breast cancer complicated with T2DM， and 788 cases without diabetes were randomly selected as non-T2DM group. The clinicopathological features and prognosis of the two groups were compared. Then two groups were matched by 1∶1 propensity matching， the disease-free survival (DFS) and breast cancer-specific survival (BCSS) were analyzed by Kaplan-Meier method， and factors influencing the recurrence of breast cancer and prognosis of patients were examined by Cox regression analysis. ［Results］ The average age was older， the tumor size was larger， the histological grade was higher， the DFS and BCSS were shorter in T2DM patients than those in non-T2DM patients (all P<0.05). Multivariate Cox regression analysis indicated that T2DM was an independent factor for prognosis of breast cancer patients (HR=1.760， 95%CI： 1.101~2.672). and also an independent factor for breast cancer-specific death (HR=1.724， 95%CI： 1.018~3.122). ［Conclusion］ The prognosis of breast cancer patients complicated with T2DM is relatively poor， and special attention should be given to this group of patients. |
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