| 童继玉,赵梦娜,杨丹妮,等.老年营养风险指数对老年上皮性卵巢癌预后的评估价值[J].肿瘤学杂志,2023,29(11):942-947. |
| 老年营养风险指数对老年上皮性卵巢癌预后的评估价值 |
| Geriatric Nutritional Risk Index for Predicting Survival of Elderly Patients with Epithelial Ovarian Cancer |
| 投稿时间：2023-09-15 |
| DOI：10.11735/j.issn.1671-170X.2023.11.B008 |
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| 中文关键词: 上皮性卵巢癌 老年营养风险指数 生存分析 |
| 英文关键词:epithelial ovarian cancer geriatric nutritional risk index survival analysis |
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| 摘要点击次数: 256 |
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| 中文摘要: |
| 摘 要：［目的］ 探究治疗前老年营养风险指数（geriatric nutritional risk index，GNRI）对老年上皮性卵巢癌患者预后的影响。［方法］ 回顾性收集2017年1月至2021年12月期间于武汉大学中南医院就诊、年龄≥65岁的老年上皮性卵巢癌患者125例，收集患者的基本临床资料及生存资料。依据GNRI的界值将患者分为高、低GNRI组，采用卡方检验及非参数检验分析GNRI与老年上皮性卵巢癌患者各临床病理参数之间的关系，采用Kaplan-Meier法进行生存分析； 多因素Cox回归分析探索生存的影响因素。［结果］ 相比较于高GNRI（≥99.11，n=58）组，低GNRI（<99.11，n=67）组患者中FIGO分期更晚（χ2=8.774，P=0.012）、白蛋白水平更低（χ2=35.704，P＜0.001）、接受初始肿瘤细胞减灭术的患者比例更少（88.8% vs 69.1%，P=0.040）、中位住院时间更长［17（13，21） d vs 20（16，25） d，P=0.019］。多因素Cox回归分析结果显示，低GNRI（HR=1.383，95%CI：1.267~4.934，P=0.030）、未接受新辅助化疗（HR=2.218，95%CI：2.020~41.823，P=0.004）及术中残余瘤为R2（HR=1.503，95%CI：1.101~18.342，P=0.036）的患者总生存期缩短。［结论］ GNRI与老年上皮性卵巢癌患者肿瘤分期、白蛋白水平以及住院时间相关。GNRI是老年上皮性卵巢癌患者生存时间的独立预后因素。 |
| 英文摘要: |
| Abstract：［Objective］ To assess the prediction value of geriatric nutritional risk index(GNRI) for survival of elderly patients with epithelial ovarian cancer(EOC) . ［Methods］ The clinical data of 125 patients with epithelial ovarian cancer aged ≥65 years old admitted to Zhongnan Hospital of Wuhan University from January 2017 to December 2021 were retrospectively analyzed. According to cut-off value of GNRI patients were divided into high GNRI group(GNRI≥99.11，n=58) and low GNRI group (GNRI<99.11，n=67). Chi-square test and non-parametric test were used to analyze the relationship between GNRI and clinicopathological parameters of patients. Kaplan-Meier method was used to analyze the overall survival of patients. The risk factors influencing the survival of patients were analyzed with multivariate Cox regression. ［Results］ Compared with the high GNRI group， low GNRI group had a higher proportion of patients with FIGO stage Ⅳ（χ2=8.774， P=0.012）， low blood albumin levels（χ2=35.704， P＜0.001）， not receiving primary debulking surgery (88.8% vs 69.1%， P=0.040)， and a longer length of hospital stay ［17（13， 21） d vs 20（16， 25） d， P=0.019］. Multivariate Cox regression analysis showed that low GNRI (HR=1.383， 95%CI：1.267~4.934， P=0.030)， no preoperative neoadjuvant chemotherapy (HR=2.218， 95%CI：2.020~41.823， P=0.004) and R2 residual tumor (HR=1.503， 95%CI：1.101~18.342， P=0.036) were risk factors of shorter overall survival. ［Conclusion］ GNRI is associated with tumor stage， albumin level and length of hospital stay in elderly patients with EOC. Low GNRI is an independent risk factor for shorter overall survival in elderly patients with EOC. |
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